SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12403
Abstract: The ATR/CHK1 pathway is a key effector of cellular response to DNA damage and therefore is a critical regulator of genomic stability. While the ATR/CHK1 pathway is often inactivated by mutations, CHK1 itself is rarely… read more here.
Keywords: chk1; response glucose; glucose deprivation; deprivation ... See more keywords
Ubiquitin E3 ligase β‐TrCP negatively regulates surface protein of hepatitis B virus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28620
Abstract: Chronic hepatitis B (CHB) still cannot be cured currently, while the pursuit of a functional cure seems to be an accessible goal, in which the condition mainly depends on the serum hepatitis B surface antigen… read more here.
Keywords: hbsag; trcp; ubiquitin ligase; hbsag levels ... See more keywords
β-TrCP suppresses the migration and invasion of trophoblast cells in preeclampsia by down-regulating Snail.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112230
Abstract: Insufficient trophoblast invasion has been shown to contribute to the occurrence and progression of preeclampsia (PE). Recently, beta-transducin repeat containing E3 ubiquitin protein (β-TrCP) was shown to function as a ubiquitination regulator in regulating the… read more here.
Keywords: invasion; trcp; trophoblast; cell ... See more keywords
Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.5b00409
Abstract: NF-κB is a major transcription factor whose activation is triggered through two main activation pathways: the canonical pathway involving disruption of IκB-α/NF-κB complexes and the alternative pathway whose activation relies on the inducible proteolysis of… read more here.
Keywords: p100; inhibitory protein; trcp; interaction ... See more keywords
TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00574-1
Abstract: Tribbles homolog 2 (TRIB2) is known to boost liver tumorigenesis via regulating Ubiquitin (Ub) proteasome system (UPS). At least two ways are involved, i.e., acts as an adaptor protein to modulate ubiquitination functions of certain… read more here.
Keywords: ferroptosis; trcp; liver cancer; trib2 ... See more keywords
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1813504116
Abstract: Significance Vaccinia virus (VACV) encodes many proteins that inhibit innate immunity. For instance, protein A49 inhibits NF-κB activation by binding to β-TrCP. Here we show that A49 is phosphorylated on serine 7 and that this… read more here.
Keywords: vaccinia virus; a49; trcp; activation ... See more keywords
Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad012
Abstract: Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumour suppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, we observed… read more here.
Keywords: trcp; hcc; hltf; p62 mtor ... See more keywords
p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0049
Abstract: Snail is a key regulator of epithelial-mesenchymal transition (EMT) which is a major step in tumor metastasis. While the induction of Snail transcription precedes EMT, post-translational regulation especially phosphorylation of Snail, is critical for determining… read more here.
Keywords: p38; snail; trcp; phosphorylation ... See more keywords
miR-200b-3p antagomir inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model through regulating β-TrCP
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research"
DOI: 10.2139/ssrn.4166319
Abstract: BACKGROUND Hypoxia-ischemic brain damage (HIBD) is a primary cause of morbidity and disability in survivors of preterm infants. We previously discovered that miR-200b-3p plays an important role in HIBD via targeting Slit2. This study was… read more here.
Keywords: glucose deprivation; trcp; mir 200b; 200b antagomir ... See more keywords
Inter-Fighting between Influenza A Virus NS1 and β-TrCP: A Novel Mechanism of Anti-Influenza Virus
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112426
Abstract: Influenza A virus (IAV) prevents innate immune signaling during infection. In our previous study, the production of pro-inflammatory cytokines was associated with Cullin-1 RING ligase (CRL1), which was related to NF-κB activation. However, the underlying… read more here.
Keywords: trcp; novel mechanism; virus; influenza virus ... See more keywords
CD147 confers temozolomide resistance of glioma cells via the regulation of β-TrCP/Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.60894
Abstract: Background: Drug resistance is one of the biggest challenges in cancer therapy. temozolomide (TMZ) represents the most important chemotherapeutic option for glioma treatment. However, the therapeutic efficacy of TMZ remains very limited due to its… read more here.
Keywords: glioma; cd147; resistance glioma; tmz ... See more keywords