Activation of the β-TrCP/IκBα/inflammation axis limits the sensitivity of liver cancer cells to neddylation inhibition
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DOI: 10.3892/or.2022.8416
Abstract: Upregulation of protein neddylation occurs in numerous types of human cancer, including liver cancer. MLN4924, a potent neddylation-inhibiting pharmacological agent, demonstrates anticancer ability in numerous cancers. However, the sensitivity of MLN4924 in liver cancer remains… read more here.
Keywords: cancer; liver cancer; mln4924; trcp inflammation ... See more keywords