The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
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DOI: 10.1128/mcb.00563-21
Abstract: Nrf2 activates cytoprotective gene expression, and Nrf2 activity is regulated through at least two protein degradation pathways: the Keap1-mediated and β-TrCP-mediated pathways. To address the relative contributions of these pathways, we generated knock-in mouse lines… read more here.
Keywords: mediated pathway; trcp mediated; keap1 mediated; nrf2 activity ... See more keywords
SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation
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DOI: 10.1136/gutjnl-2022-327492
Abstract: Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumour with limited treatment options. Here, we identified syndecan binding protein (SDCBP), also known as syntenin1, as a novel targetable factor in promoting PDAC tumour progression.… read more here.
Keywords: preventing yap1; sdcbp promotes; progression; trcp mediated ... See more keywords