Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?
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DOI: 10.1002/mds.29058
Abstract: Neurodegenerative proteinopathies are defined as a class of neurodegenerative disorders, with either genetic or sporadic age‐related onset, characterized by the pathological accumulation of aggregated protein deposits. These mainly include Alzheimer's disease (AD), Parkinson's disease (PD),… read more here.
Keywords: neurodegenerative proteinopathies; disease; protein degradation; treat neurodegenerative ... See more keywords
Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer’s Disease, Lithium, and Autophagy
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DOI: 10.3390/ijms22010189
Abstract: Lithium is the prototype mood-stabilizer used for acute and long-term treatment of bipolar disorder. Cumulated translational research of lithium indicated the drug’s neuroprotective characteristics and, thereby, has raised the option of repurposing it as a… read more here.
Keywords: treat neurodegenerative; justification treat; alzheimer disease; drug ... See more keywords
A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation
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DOI: 10.3390/ijms24021615
Abstract: SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial proteins including metabolic enzymes and respiratory chain components. Although SIRT3’s functions in peripheral tissues are well established, the significance of its downregulation in neurodegenerative diseases… read more here.
Keywords: promising strategy; strategy treat; sirt3; diseases sirt3 ... See more keywords