Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin‐induced tumor necrosis factor‐dependent liver injury in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3585
Abstract: Idiosyncratic drug‐induced liver injury (iDILI) has a poorly understood pathogenesis. However, iDILI is often associated with inflammatory stress signals in human patients as well as animal models. Tumor necrosis factor (TNF) and neutrophils play a… read more here.
Keywords: tvx; treated mice; tumor necrosis; liver injury ... See more keywords
Transmission electron microscopy of the liver mitochondria of N-Nitrosodibutylamine-treated mice.
Sign Up to like & getrecommendations! Published in 2021 at "Microscopy research and technique"
DOI: 10.1002/jemt.23842
Abstract: N-Nitrosodibutylamine (DBN) has been found in a wide variety of products because of the nitrosation of amines present in these products. An extensive series of synthesis and carcinogenicity studies of various compounds related to DBN… read more here.
Keywords: microscopy; liver mitochondria; treated mice; electron microscopy ... See more keywords
Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12404
Abstract: BACKGROUND The gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEPs) on immunoregulation and GM in cyclophosphamide (CTX)-treated mice were… read more here.
Keywords: hericium erinaceus; gut microbiota; erinaceus polysaccharides; treated mice ... See more keywords
Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1676-z
Abstract: DMF-mediated anti-inflammatory, anti-oxidative or a synergism of both effects may be sufficient to propagate nerve regeneration in a primary mechanical injury model. To evaluate the efficacy of DMF during Wallerian degeneration, we performed sciatic nerve… read more here.
Keywords: anti inflammatory; days post; dmf; post crush ... See more keywords
Effects of Silver Nanoparticles on Burn Wound Healing in a Mouse Model
Sign Up to like & getrecommendations! Published in 2019 at "Biological Trace Element Research"
DOI: 10.1007/s12011-019-01729-z
Abstract: Healing of injuries caused by exposure to heat has been discussed in many studies, although a few drugs have been shown to produce satisfactory results. In this study, 100 healthy mice randomly allocated into four… read more here.
Keywords: wound healing; effects silver; silver nanoparticles; model ... See more keywords
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10069-6
Abstract: Atrial fibrillation (AF) is common, yet there is no preventive therapy for AF. We tested the efficacy of AMP-activated protein kinase (AMPK) activators, metformin, and aspirin, in primary prevention of AF in cardiac-specific liver kinase… read more here.
Keywords: atrial fibrillation; activated protein; treated mice; activation ... See more keywords
Evaluation of antitumor activity of Urena lobata against Ehrlich ascites carcinoma treated mice
Sign Up to like & getrecommendations! Published in 2018 at "Oriental Pharmacy and Experimental Medicine"
DOI: 10.1007/s13596-018-0342-x
Abstract: The search for cancer therapy with natural products continues to be a global effort. Many natural products have been tested globally against various cancer cell lines. Urena lobata Linn. (U. lobata) has been used as… read more here.
Keywords: antitumor activity; treated mice; cell; tumor ... See more keywords
Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.01.001
Abstract: Antibiotics act on bacterial flora originally present in the intestine, and changes in the intestinal flora have various effects on the host. This study investigated changes in the protein levels of drug transporters and metabolizing… read more here.
Keywords: antibiotic treated; transporters metabolizing; drug; metabolizing enzymes ... See more keywords
Na+-K+-2Cl- cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173162
Abstract: Na+-K+-2Cl- cotransporter (NKCC) is expressed at exceptionally high levels in gastric parietal cells. Bumetanide, a potent loop diuretic that blocks NKCC, usually causes a decrease in gastric acid secretion. Endotoxaemia causes hypochlorhydria in vivo, in… read more here.
Keywords: secretion; gastric mucosa; acid secretion; treated mice ... See more keywords
The effect of tocotrienols on high-fat diet-treated mice
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.219
Abstract: Obesity is increasing in developed countries and is well known to a risk factor of severe diseases such as diabetes and Alzheimer's disease. Several kinds of evidence have been demonstrated that these diseases relate to… read more here.
Keywords: fat diet; diet treated; effect; treated mice ... See more keywords
Polysaccharides from ginseng leaves inhibit tumor metastasis via macrophage and NK cell activation.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.055
Abstract: In this study, we purified the polysaccharide fraction (GS-P) from the leaves of Panax ginseng C.A. Meyer and analyzed its monosaccharide composition and antitumor and antimetastatic activity in vitro and in vivo. GS-P is a… read more here.
Keywords: polysaccharides ginseng; metastasis; treated mice; ginseng leaves ... See more keywords