Expressions of PD-L1 and Nectin-4 in urothelial cancer patients treated with pembrolizumab
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02717-3
Abstract: Recently, the standard of care for advanced urothelial cancer (UC) has been changed by developing immune-checkpoint inhibitors (ICIs). However, its response rate is limited to 20–30%. The identification of biomarkers to predict the therapeutic effects… read more here.
Keywords: urothelial cancer; patients treated; treated pembrolizumab; tumor cells ... See more keywords
Impact of germline HLA genotypes on clinical outcomes in patients with urothelial cancer treated with pembrolizumab
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15488
Abstract: Human leukocyte antigen class I (HLA‐I) genotypes are suggested to influence the cancer response to checkpoint blockade immunotherapy. This study assessed the impact of germline HLA genotypes on clinical outcomes in patients with chemoresistant advanced… read more here.
Keywords: outcomes patients; hla; treated pembrolizumab; hla genotypes ... See more keywords
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005248
Abstract: Background Immunotherapy is currently part of the standard of care for patients with advanced-stage non-small cell lung cancer (NSCLC). However, many patients do not respond to this treatment, therefore combination strategies are being explored to… read more here.
Keywords: immunological abscopal; abscopal effect; treated pembrolizumab; combination ... See more keywords
Abstract PO-131: Inter-tumoral heterogeneity of progressive disease in melanoma patients treated with pembrolizumab
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.tumhet2020-po-131
Abstract: Introduction: In clinical trials of patients treated with pembrolizumab, RECIST-defined progressive disease (PD) is often assumed to reflect generalized lack or loss of efficacy. However, mixed lesion-level responses within a given patient may reflect more… read more here.
Keywords: heterogeneity; treated pembrolizumab; level; progressive disease ... See more keywords
Is the occurrence of higher adverse effects associated with better oncological outcome in metastatic urothelial carcinoma patients treated with pembrolizumab?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.7_suppl.405
Abstract: 405 Background: Pembrolizumab is an anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibody and a recently approved and long-awaited drug for the treatment of metastatic urothelial carcinoma (UC). It is an immune checkpoint inhibitor, which has… read more here.
Keywords: treated pembrolizumab; urothelial carcinoma; occurrence; high groups ... See more keywords
Medullary carcinoma of the duodenum treated with pembrolizumab: a case report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-755
Abstract: Background Medullary carcinoma (MC) is a recognized histologic subtype of colorectal cancer characterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate. However, MC originating from the small intestine is exceedingly rare, with only nine cases… read more here.
Keywords: duodenum; medullary carcinoma; treated pembrolizumab; report ... See more keywords
Association Between Immune-Related Adverse Events and Efficacy and Changes in the Relative Eosinophil Count Among Patients with Advanced Urothelial Carcinoma Treated by Pembrolizumab
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Management and Research"
DOI: 10.2147/cmar.s360473
Abstract: Background To evaluate the association between immune-related adverse events (irAEs) and the clinical outcomes and also between irAEs and the post-treatment changes in the relative eosinophil count (REC) in advanced urothelial carcinoma (UC) patients treated… read more here.
Keywords: association immune; treated pembrolizumab; immune related; iraes ... See more keywords
Early Progression in Non-Small Cell Lung Cancer (NSCLC) with High PD-L1 Treated with Pembrolizumab in First-Line Setting: A Prognostic Scoring System Based on Clinical Features
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13122935
Abstract: Simple Summary Immune checkpoint inhibitors demonstrated a survival advantage in the first-line setting in patients with non-oncogene addicted non-small cell lung cancer (NSCLC) and PD-L1 expression ≥50%. However, some patients have detrimental effects from this… read more here.
Keywords: line setting; line; first line; treated pembrolizumab ... See more keywords
Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizumab.
Sign Up to like & getrecommendations! Published in 2020 at "Reumatismo"
DOI: 10.4081/reumatismo.2020.1297
Abstract: In this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for… read more here.
Keywords: report polymyalgia; treated pembrolizumab; case; three different ... See more keywords
Beneath the surface: a case report of metastatic iridociliary ring melanoma treated with pembrolizumab.
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos brasileiros de oftalmologia"
DOI: 10.5935/0004-2749.20230046
Abstract: Iridociliary ring melanoma is an uncommon type of uveal melanoma. Clinical manifestation varies from asymptomatic cases to masquerade syndromes mimicking refractory glaucoma. Treatment options include radiotherapy and enucleation. Management of metastatic uveal melanoma remains discouraging.… read more here.
Keywords: melanoma; ring melanoma; iridociliary ring; case ... See more keywords