Sodium benzoate induces neurobehavioral deficits and brain oxido-inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23010
Abstract: BACKGROUND Sodium benzoate (SB) is a widely used food preservative. However, excessive intake of a high dose of SB poses a risk of neurotoxicity. Ascorbic acid (AA) is a naturally occurring antioxidant found in fruits… read more here.
Keywords: treated rats; rats ameliorative; ascorbic acid; sodium benzoate ... See more keywords
Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Toxicology"
DOI: 10.1002/tox.23129
Abstract: Resveratrol (Res), a polyphenolic compound that exerts mitigating consequences against various insults due to its antioxidant, anti‐inflammatory, and immunomodulatory properties. Sulfoxaflor (SFX), a neonicotinoid insecticide, has been used worldwide and leading to deleterious effects on… read more here.
Keywords: resveratrol; res treatment; treatment; effect ... See more keywords
Fibroblast growth factor-2 enhancement of extinction recall depends on the success of within-session extinction training in rats: a re-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5032-3
Abstract: RationaleOne approach to improving exposure therapy for anxiety disorders has focused on developing pharmacological adjuncts to enhance extinction, but these efforts have produced modest success in clinical trials. Understanding the factors that predict the efficacy… read more here.
Keywords: within session; extinction recall; extinction; extinction training ... See more keywords
Dietary flaxseed oil inhibits kidney NF-kappa B activation and pro-inflammatory cytokine expression in cisplatin-treated rats
Sign Up to like & getrecommendations! Published in 2018 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-018-2871-6
Abstract: The current study explores the anti-inflammatory effect of flaxseed oil (FXO) on cisplatin (CP)-induced renal damage. Rats prefed with normal experimental diets (normal/FXO diet) for 10 days were administered 30 mg kg−1 and 50 mg kg−1 i.p. CP in a single… read more here.
Keywords: cisplatin; flaxseed oil; fxo; treated rats ... See more keywords
Cardiovascular dysfunction associated with neurodegeneration in an experimental model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2016.12.008
Abstract: Patients with Parkinson's disease (PD) exhibit both motor and non-motor symptoms. Among the non-motor symptoms, cardiovascular autonomic dysfunction is frequently observed. Here, we evaluated baroreflex function, vascular reactivity and neuroanatomical changes in brainstem regions involved… read more here.
Keywords: dysfunction; cardiovascular dysfunction; model; treated rats ... See more keywords
Ghrelin fibers from lateral hypothalamus project to nucleus tractus solitaries and are involved in gastric motility regulation in cisplatin-treated rats
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.01.004
Abstract: Ghrelin can alleviate cancer chemotherapy-induced dyspepsia in rodents, though the neural mechanisms involved are not known. Therefore, ghrelin projections from the lateral hypothalamus (LH) and its involvement in the regulation of gastric motility in cisplatin-treated… read more here.
Keywords: cisplatin; treated rats; motility; gastric motility ... See more keywords
Subchronic exposure to Kafura; its neurotoxic potentials in young adult female Wistar rats
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03514
Abstract: Background Kafura pelebe (camphor) {C10H16O} is a chemical substance used mostly amongst the Yoruba ethnic group in Western Nigeria to treat infantile colic during early childhood. This study assess the neurotoxic potentials of Kafura following… read more here.
Keywords: neurotoxic potentials; control; exposure; kafura ... See more keywords
Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00703
Abstract: Chemotherapy utilizing cytotoxic drugs, such as paclitaxel (PTX), is still a commonly used therapeutic approach to treat both localized and metastasized cancers. Unlike traditional regimens in which PTX is administered at the maximum tolerated dose,… read more here.
Keywords: polyester nanoparticle; peripheral neuropathy; ptx; induced peripheral ... See more keywords
Potential of curcumin and resveratrol as biochemical and biophysical modulators during lung cancer in rats
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2018.1523921
Abstract: Abstract The present study explored chemopreventive aspects of curcumin and resveratrol in the experimental model of lung carcinogenesis in rats. The main aim was to establish efficacy of combined phytochemicals treatment over individual treatments in… read more here.
Keywords: resveratrol; curcumin resveratrol; treated rats; cancer ... See more keywords
Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Research"
DOI: 10.1080/01616412.2019.1596206
Abstract: ABSTRACT Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported… read more here.
Keywords: protein; endoplasmic reticulum; rutin hydrate; stress ... See more keywords
Cyclooxygenase-2 is a critical determinant of angiotensin II-induced vascular remodeling and stiffness in resistance arteries of ouabain-treated rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003242
Abstract: Objective: To investigate the role of angiotensin II/AT1 receptor signaling and/or cyclooxygenase-2 (COX-2) activation on vascular remodeling and stiffening of the mesenteric resistance arteries (MRA) of ouabain-treated rats. Methods: Ouabain-treated (OUA, 30 μg kg/day for 5 weeks) and… read more here.
Keywords: angiotensin; cox; vascular remodeling; ouabain treated ... See more keywords