Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naïve Juvenile Macaques
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DOI: 10.1128/iai.00558-22
Abstract: Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy (ART) reduces, but does not abolish, this risk in children with HIV. ABSTRACT Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy… read more here.
Keywords: treated siv; tuberculosis; antiretroviral therapy; infection ... See more keywords
IFNα-blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.
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DOI: 10.1172/jci.insight.153046
Abstract: Type I interferons (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic TI-IFN signaling in the context of antiretroviral therapy (ART)-treated HIV infection also facilitates… read more here.
Keywords: ifn; ifn blockade; art treated; siv infection ... See more keywords