Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01158
Abstract: CB1 receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into… read more here.
Keywords: leveraging peripheral; treating metabolic; tetrahydropyridazine based; amidine ... See more keywords
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00483
Abstract: Ceramide synthases (CerS) are central enzymes required for the de-novo synthesis of ceramides and other sphingolipids. They catalyze the addition of different acyl-chains to a sphingoid base, and thus account for much of the rich… read more here.
Keywords: drug targets; treating metabolic; ceramide synthases; synthases attractive ... See more keywords
Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2017.00049
Abstract: Lifestyle interventions incorporating both diet and exercise strategies remain cornerstone therapies for treating metabolic disease. Carbohydrate-restriction and high-intensity interval training (HIIT) have independently been shown to improve cardiovascular and metabolic health. Carbohydrate-restriction reduces postprandial hyperglycemia,… read more here.
Keywords: restriction; intensity interval; treating metabolic; high intensity ... See more keywords
Bioactive Compounds in Sea Buckthorn and their Efficacy in Preventing and Treating Metabolic Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Foods"
DOI: 10.3390/foods12101985
Abstract: Sea buckthorn (Hippophae rhamnoides L. or Elaeagnus rhamnoides L.) is a plant that has long been used as a Chinese herbal medicine. This species is known to contain numerous bioactive components, including polyphenols, fatty acids,… read more here.
Keywords: metabolic syndrome; bioactive compounds; sea buckthorn; treating metabolic ... See more keywords