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Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.48355
Abstract: This survey study examines the understanding of aducanumab and attitudes toward its potential outcomes among older Americans after the drug's approval by the US Food and Drug Administration (FDA) for the treatment for Alzheimer disease.
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Keywords:
among older;
approval;
alzheimer disease;
treatment alzheimer ... See more keywords
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1
Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02666-6
Abstract: A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted…
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Keywords:
alzheimer disease;
base derivatives;
agents treatment;
treatment alzheimer ... See more keywords
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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.022
Abstract: A series of salicylamide derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors. They showed good…
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Keywords:
alzheimer disease;
treatment;
salicylamide derivatives;
agents treatment ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.009
Abstract: A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good…
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Keywords:
mannich base;
alzheimer disease;
aurone mannich;
base derivatives ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.054
Abstract: A series of scutellarein-O-acetamidoalkylbenzylamines derivatives were designed based on a multitarget-directed ligands strategy for the treatment of Alzheimer's disease. Among these compounds, compound T-22 demonstrated excellent acetylcholinesterase inhibitory, moderate inhibitory effects on self-induced Aβ1-42 aggregation,…
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Keywords:
alzheimer disease;
scutellarein acetamidoalkylbenzylamines;
treatment alzheimer;
induced aggregation ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.006
Abstract: In this paper, the preparation of a new class of multi-target-directed ligands (MTDLs) based on a 7-amino-1,4-dihydro-2H-isoquilin-3-one, whose lead (compound I) showed promising properties in acetylcholinesterase (AChE) inhibitory activity [1], is described. The results of…
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Keywords:
bace;
ache;
isoquilin one;
amino dihydro ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.12.080
Abstract: A series of LX2343 derivatives were designed, synthesized and evaluated as neuroprotective agents for Alzheimer's disease (AD) in vitro. Most of the compounds displayed potent neuroprotective activities. Especially for compound A6, exhibited a remarkable EC50 value…
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Keywords:
lx2343 derivatives;
neuroprotective agents;
alzheimer disease;
disease ... See more keywords
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Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.06.032
Abstract: Aim: The present study aims to investigate the pharmacokinetics and pharmacodynamics of HLS‐3, a tacrine dimer with high anti‐acetylcholinesterase activity for the treatment of Alzheimer's disease. Main methods: In vitro Calu‐3 and Caco‐2 cell monolayer…
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Keywords:
hls;
alzheimer disease;
treatment alzheimer;
intranasal delivery ... See more keywords
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1
Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00273
Abstract: The main purpose of the present study was to synthesize graphene quantum dots (GQDs)from the flowers of Clitoria ternatea with the help of one-pot microwave-assisted green synthesis for the treatment of Alzheimer's disease. Further, the…
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Keywords:
graphene quantum;
microscopy;
clitoria ternatea;
spectroscopy ... See more keywords
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1
Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00520
Abstract: Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and…
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Keywords:
compound c10;
treatment alzheimer;
ache;
novel chromanone ... See more keywords
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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210766119
Abstract: Significance Alzheimer’s disease (AD) associates closely with misfolding and aggregation of Aβ protein. Inability to detect early Aβ aggregates at presymptomatic stages has limited efforts to diagnose and treat AD. Employing a theranostic approach, neurotoxic…
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Keywords:
disease;
diagnosis treatment;
alzheimer disease;
early diagnosis ... See more keywords