REMeDio: a proof-of-concept neuroprotection study for prodromal synucleinopathies.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of neurology"
DOI: 10.1111/ene.14664
Abstract: OBJECTIVE To explore the feasibility of a neuroprotection trial in prodromal synucleinopathy, using idiopathic REM sleep behavior disorder (iRBD) as the target population and 123 I-FP-CIT-SPECT as a biomarker of disease progression. METHODS Consecutive iRBD… read more here.
Keywords: treatment; cit spect; arm; 123 cit ... See more keywords
Power and sample size calculations for cluster randomized trials with binary outcomes when intracluster correlation coefficients vary by treatment arm
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Trials"
DOI: 10.1177/17407745211059845
Abstract: Background/Aims Generalized estimating equations are commonly used to fit logistic regression models to clustered binary data from cluster randomized trials. A commonly used correlation structure assumes that the intracluster correlation coefficient does not vary by… read more here.
Keywords: size; correlation; treatment arm; treatment ... See more keywords