Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01643
Abstract: Acid sphingomyelinase (ASM), which regulates sphingolipid metabolism and lipid signaling, has been considered as a new potential target for the treatment of atherosclerosis. In this study, a series of benzene-heterocyclic-based ASM inhibitors were rationally designed,… read more here.
Keywords: discovery novel; novel hydroxy; asm; atherosclerosis ... See more keywords
Anti-Oxidative, Anti-Apoptotic, and M2 Polarized DSPC Liposome Nanoparticles for Selective Treatment of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s384675
Abstract: Purpose Oxidative stress is one of the main pathogenic factors of atherosclerosis. However, no antioxidants have brought positive effects on the treatment of atherosclerosis. To selectively treat atherosclerosis, various means such as antioxidation, anti-apoptosis, and… read more here.
Keywords: liposome nanoparticles; anti apoptotic; atherosclerosis; treatment atherosclerosis ... See more keywords
Recent Advances: From Cell Biology to Cell Therapy in Atherosclerosis Plaque via Stent Implantation.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221028144416
Abstract: Atherosclerosis is a multifactorial result of complicated pathophysiology. Changes in the expression of polygenes, coupled with environmental and lifestyle factors, trigger a cascade of adverse events involving a variety of cell types, such as vascular… read more here.
Keywords: biology cell; cell biology; plaque; atherosclerosis ... See more keywords
Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques
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DOI: 10.3389/fchem.2022.868063
Abstract: Although research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for the treatment of atherosclerosis. Nanomaterials have recently played a unique role in many fields,… read more here.
Keywords: treatment atherosclerosis; stability; atherosclerotic plaques; treatment ... See more keywords
Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
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DOI: 10.3390/pharmaceutics12111056
Abstract: Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes.… read more here.
Keywords: nanoparticle based; atherosclerosis; treatment atherosclerosis; approaches towards ... See more keywords