Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01643
Abstract: Acid sphingomyelinase (ASM), which regulates sphingolipid metabolism and lipid signaling, has been considered as a new potential target for the treatment of atherosclerosis. In this study, a series of benzene-heterocyclic-based ASM inhibitors were rationally designed,… read more here.
Keywords: discovery novel; novel hydroxy; asm; atherosclerosis ... See more keywords
Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis.
Sign Up to like & getrecommendations! Published in 2025 at "Gut microbes"
DOI: 10.1080/19490976.2025.2452229
Abstract: ABSTRACT Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring the search for novel and effective treatments. Recent research indicates the crucial involvement… read more here.
Keywords: extracellular vesicles; treatment; progression; atherosclerosis ... See more keywords
The use of monoclonal antibodies for the treatment of atherosclerosis: current status and prospects.
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2025.71.7.9
Abstract: Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, underlying major conditions such as coronary heart disease and stroke. The pathogenesis of atherosclerosis is tightly linked to chronic inflammation and dysregulated lipid metabolism,… read more here.
Keywords: atherosclerosis; antibodies treatment; use monoclonal; treatment atherosclerosis ... See more keywords
Anti-Oxidative, Anti-Apoptotic, and M2 Polarized DSPC Liposome Nanoparticles for Selective Treatment of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s384675
Abstract: Purpose Oxidative stress is one of the main pathogenic factors of atherosclerosis. However, no antioxidants have brought positive effects on the treatment of atherosclerosis. To selectively treat atherosclerosis, various means such as antioxidation, anti-apoptosis, and… read more here.
Keywords: liposome nanoparticles; anti apoptotic; atherosclerosis; treatment atherosclerosis ... See more keywords
Macrophage-Targeted Nanomedicine for the Treatment of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s529988
Abstract: Abstract Cardiovascular and cerebrovascular diseases are the leading causes of mortality worldwide, with atherosclerosis being the primary etiology. Despite its prevalence, atherosclerosis remains inadequately controlled by conventional therapeutic interventions. The unique physicochemical properties of nanomedicine… read more here.
Keywords: treatment; atherosclerosis; targeted nanomedicine; macrophage targeted ... See more keywords
Recent Advances: From Cell Biology to Cell Therapy in Atherosclerosis Plaque via Stent Implantation.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221028144416
Abstract: Atherosclerosis is a multifactorial result of complicated pathophysiology. Changes in the expression of polygenes, coupled with environmental and lifestyle factors, trigger a cascade of adverse events involving a variety of cell types, such as vascular… read more here.
Keywords: biology cell; cell biology; plaque; atherosclerosis ... See more keywords
Platelet Membrane Biomimetic Nanoparticles Combined With UTMD to Improve the Stability of Atherosclerotic Plaques
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.868063
Abstract: Although research on the treatment of atherosclerosis has progressed recently, challenges remain in developing more effective, safer and transformative strategies for the treatment of atherosclerosis. Nanomaterials have recently played a unique role in many fields,… read more here.
Keywords: treatment atherosclerosis; stability; atherosclerotic plaques; treatment ... See more keywords
Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12111056
Abstract: Atherosclerosis, being an inflammation-associated disease, represents a considerable healthcare problem. Its origin remains poorly understood, and at the same time, it is associated with extensive morbidity and mortality worldwide due to myocardial infarctions and strokes.… read more here.
Keywords: nanoparticle based; atherosclerosis; treatment atherosclerosis; approaches towards ... See more keywords