Pathophysiology and Treatment of Canavan Disease
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DOI: 10.1007/s11064-018-2693-6
Abstract: Canavan disease is a recessively inherited vacuolar leukodystrophy caused by ASPA mutations [1–3]. ASPA encodes aspartoacylase, an oligodendroglial enzyme required for cleavage of the abundant brain amino acid N-acetyl-l-aspartate (NAA) to acetate and l-aspartate [4].… read more here.
Keywords: treatment canavan; pathophysiology treatment; canavan; canavan disease ... See more keywords