Design and characterization of α1-antitrypsin variants for treatment of contact system-driven thromboinflammation.
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DOI: 10.1182/blood.2019000481
Abstract: The contact system produces the inflammatory peptide bradykinin and contributes to experimental thrombosis. C1 esterase-inhibitor (C1INH) deficiency or gain-of-function mutations in Factor XII (FXII) cause hereditary angioedema, a life-threatening tissue swelling disease. C1INH is a… read more here.
Keywords: system; system driven; antitrypsin; treatment contact ... See more keywords