Grade 1‐2 neutropenia after first treatment for diffuse large B‐cell lymphoma is associated with a better outcome compared to grade 3‐4—A Danish population‐based cohort study
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_71
Abstract: employed multivariate Cox proportional hazard models on selected clinical variables. Training was performed on defined sets of cases identified molecularly similar for each individual case, and on all cases in the database; Cox proportional hazard… read more here.
Keywords: neutropenia first; treatment diffuse; grade neutropenia; cell ... See more keywords
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02016
Abstract: The "magic methyl effect" has facilitated the successful development of numerous pharmaceutical compounds. During the development of HsClpP activators, we found that incorporating methyl groups into the bicyclic imipridone scaffolds significantly enhanced the activator activity… read more here.
Keywords: hsclpp; clpp 2068; magic methyl; methyl effect ... See more keywords
Abstract A022: Discovery of conformationally constrained ALK2 inhibitors for the treatment of Diffuse Intrinsic Pontine Glioma (DIPG)
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.cancerchem24-a022
Abstract: Despite considerable research on new therapeutics to treat DIPG, a universally fatal grade IV pediatric CNS tumor located in the pons region of the brainstem, there has been minimal progress. Somatic missense mutations in the… read more here.
Keywords: conformationally constrained; constrained alk2; discovery conformationally; alk2 inhibitors ... See more keywords