Treatment effect of exercise training on post‐stroke depression in middle‐aged and older adults: A meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5798
Abstract: This meta‐analytic study examined the effects of exercise training on depressive symptoms in mild stroke patients and the moderating effects of exercise type, therapeutic method, culture, sex, and gross domestic product (GDP) in the patient’s… read more here.
Keywords: treatment effect; training post; effect exercise; exercise training ... See more keywords
The Influence of School Nutrition Programs on the Weight of Low‐Income Children: A Treatment Effect Analysis
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DOI: 10.1002/hec.3378
Abstract: Recent policy attempts to set high nutrition standards for the School Breakfast Program (SBP) and National School Lunch Program (NSLP) aim to improve children's health outcomes. A timely and policy-relevant task evaluates to what extent… read more here.
Keywords: school; effect; nutrition; income ... See more keywords
Quantifying the bias in the estimated treatment effect in randomized trials having interim analyses and a rule for early stopping for futility.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7242
Abstract: In this paper, we consider the potential bias in the estimated treatment effect obtained from clinical trials, the protocols of which include the possibility of interim analyses and an early termination of the study for… read more here.
Keywords: futility; treatment; interim analyses; bias ... See more keywords
Some methods for heterogeneous treatment effect estimation in high dimensions.
Sign Up to like & getrecommendations! Published in 2018 at "Statistics in medicine"
DOI: 10.1002/sim.7623
Abstract: When devising a course of treatment for a patient, doctors often have little quantitative evidence on which to base their decisions, beyond their medical education and published clinical trials. Stanford Health Care alone has millions… read more here.
Keywords: methods heterogeneous; effect estimation; treatment; heterogeneous treatment ... See more keywords
Quantifying the totality of treatment effect with multiple event-time observations in the presence of a terminal event from a comparative clinical study.
Sign Up to like & getrecommendations! Published in 2018 at "Statistics in medicine"
DOI: 10.1002/sim.7907
Abstract: To evaluate the totality of one treatment's benefit/risk profile relative to an alternative treatment via a longitudinal comparative clinical study, the timing and occurrence of multiple clinical events are typically collected during the patient's follow-up.… read more here.
Keywords: treatment; time; study; event ... See more keywords
Assessment of heterogeneous treatment effect estimation accuracy via matching.
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DOI: 10.1002/sim.9010
Abstract: We study the assessment of the accuracy of heterogeneous treatment effect (HTE) estimation, where the HTE is not directly observable so standard computation of prediction errors is not applicable. To tackle the difficulty, we propose… read more here.
Keywords: estimation; heterogeneous treatment; accuracy; treatment effect ... See more keywords
Using a surrogate with heterogeneous utility to test for a treatment effect
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DOI: 10.1002/sim.9602
Abstract: The primary benefit of identifying a valid surrogate marker is the ability to use it in a future trial to test for a treatment effect with shorter follow‐up time or less cost. However, previous work… read more here.
Keywords: test treatment; treatment effect; surrogate; test ... See more keywords
Consistent inverse probability of treatment weighted estimation of the average treatment effect with mismeasured time‐dependent confounders
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DOI: 10.1002/sim.9629
Abstract: In longitudinal studies, the inverse probability of treatment weighted (IPTW) method is commonly employed to estimate the effect of time‐dependent treatments on an outcome of interest. However, it has been documented that when the confounders… read more here.
Keywords: treatment effect; effect; measurement error; method ... See more keywords
On assessing survival benefit of immunotherapy using long‐term restricted mean survival time
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DOI: 10.1002/sim.9662
Abstract: The pattern of the difference between two survival curves we often observe in randomized clinical trials for evaluating immunotherapy is not proportional hazards; the treatment effect typically appears several months after the initiation of the… read more here.
Keywords: long term; time; treatment effect; survival ... See more keywords
Impact of follow-up on generalized pairwise comparisons for estimating the irinotecan benefit in advanced/metastatic gastric cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106400
Abstract: BACKGROUND AND OBJECTIVES The net treatment effect (∆) is a new method to assess the treatment benefit that combines multiple time-to-event, binary and continuous endpoints according to a pre-specified sequence. It represents the net probability… read more here.
Keywords: advanced metastatic; treatment; impact follow; net treatment ... See more keywords
Personalized medicine enrichment design for DHA supplementation clinical trial
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2017.01.002
Abstract: Personalized medicine aims to match patient subpopulation to the most beneficial treatment. The purpose of this study is to design a prospective clinical trial in which we hope to achieve the highest level of confirmation… read more here.
Keywords: medicine; trial; treatment; personalized medicine ... See more keywords