Modelling drugs interaction in treatment-experienced patients on antiretroviral therapy
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DOI: 10.1007/s00500-020-05024-1
Abstract: Understanding pharmacology and drug resistance patterns plus appropriate use of laboratory testing is vital for managing treatment-experienced patients with new agents. While we acknowledge that patients with extensive drug resistance now have multiple options for… read more here.
Keywords: treatment; drug; drugs interaction; experienced patients ... See more keywords
Treatment-Experienced Patients on Third-Line Therapy: A Retrospective Cohort of Treatment Outcomes at the HIV Advanced Treatment Centre, University Teaching Hospital, Zambia.
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DOI: 10.1089/aid.2021.0208
Abstract: INTRODUCTION While antiretroviral therapy (ART) uptake continues to increase across sub-Saharan Africa, emergence of drug-resistant HIV mutations poses significant challenges to management of treatment-experienced patients with virologic failure. In Zambia, new third-line ART (TLART) guidelines… read more here.
Keywords: experienced patients; third line; university teaching; zambia ... See more keywords
Long-term efficacy of dolutegravir in treatment-experienced subjects failing therapy with HIV-1 integrase strand inhibitor-resistant virus
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DOI: 10.1093/jac/dkx371
Abstract: Objectives This study evaluated the virological efficacy of dolutegravir 50 mg twice daily in 190 HIV-1 failing antiretroviral-experienced patients with previous exposure to first-generation integrase strand transfer inhibitor (INSTI) over a 5 year follow-up using data from… read more here.
Keywords: dolutegravir twice; efficacy dolutegravir; treatment; hiv ... See more keywords
Significant decline in heavily treatment experienced persons with HIV with limited antiretroviral treatment options in the US, 2000-2017.
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DOI: 10.1097/qad.0000000000002679
Abstract: OBJECTIVE Historically, a high burden of resistance to antiretroviral therapy (ART) in heavily treatment experienced (HTE) persons with HIV (PWH) resulted in limited treatment options (LTO). We evaluated the prevalence, risk factors, and virologic control… read more here.
Keywords: treatment; lto; treatment experienced; heavily treatment ... See more keywords
Pharmacokinetics and pharmacodynamics of adult dolutegravir tablets in treatment-experienced children with HIV weighing at least 20 kg.
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DOI: 10.1097/qad.0000000000003576
Abstract: OBJECTIVE Limited pharmacokinetic/pharmacodynamic data are a barrier to the well tolerated scale-up of dolutegravir-based antiretroviral therapy (ART) in children. We examined the pharmacokinetic/pharmacodynamic of the adult film-coated dolutegravir 50 mg tablets in children with HIV infection… read more here.
Keywords: hiv weighing; weighing least; experienced children; children hiv ... See more keywords
Opening the door on entry inhibitors in HIV: Redefining the use of entry inhibitors in heavily treatment experienced and treatment‐limited individuals living with HIV
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DOI: 10.1111/hiv.13288
Abstract: Entry inhibitors are a relatively new class of antiretroviral therapy and are typically indicated in heavily treatment experienced individuals living with HIV. Despite this, there is no formal definition of ‘heavily treatment experienced’. Interpretation of… read more here.
Keywords: entry inhibitors; individuals living; treatment; treatment experienced ... See more keywords
Week 96 Genotypic and Phenotypic Results of the Fostemsavir Phase 3 BRIGHTE Study in Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1
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DOI: 10.1128/aac.01751-21
Abstract: In the phase 3 BRIGHTE study in heavily treatment-experienced adults with multidrug-resistant HIV-1, fostemsavir plus optimized background therapy (OBT) resulted in sustained rates of virologic suppression through 96 weeks. HIV-1 RNA read more here.
Keywords: phase brighte; brighte study; treatment; treatment experienced ... See more keywords
Outcomes of etravirine-based antiretroviral treatment in treatment-experienced children and adolescents living with HIV in Europe and Thailand
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DOI: 10.1177/13596535221092182
Abstract: Background Etravirine (ETR) is approved as a component of second or third-line antiretroviral treatment (ART) for children living with HIV. We assessed the outcomes of ETR-based ART in children in routine care in Europe and… read more here.
Keywords: europe thailand; living hiv; etr start; antiretroviral treatment ... See more keywords
Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy
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DOI: 10.1177/2325958219867325
Abstract: Simplifying or switching antiretroviral therapy (ART) in treatment-experienced people living with HIV (PLWH) may improve adherence, tolerability, toxicities, and/or drug–drug interactions. The purpose of this review is to critically evaluate the literature for efficacy and… read more here.
Keywords: antiretroviral therapy; switch simplification; treatment experienced; simplification strategies ... See more keywords
Real world experience with the all-oral interferon free regimen for the treatment of chronic hepatitis c virus infection in the Lebanese population.
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DOI: 10.3855/jidc.10028
Abstract: INTRODUCTION The treatment of hepatitis C has dramatically improved since the introduction of the new Direct-Acting Antivirals (DAAs). The aim of this study is to assess the effectiveness and safety of all oral DAAs with… read more here.
Keywords: hepatitis; treatment; infection; daas ... See more keywords