Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00193
Abstract: Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the… read more here.
Keywords: design synthesis; fragile syndrome; allosteric inhibitors; pde4d ... See more keywords
Parent and Caregiver Perspectives towards Cannabidiol as a Treatment for Fragile X Syndrome
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DOI: 10.3390/genes13091594
Abstract: Cannabidiol (CBD) is a non-intoxicating chemical in cannabis plants that is being investigated as a candidate for treatment in Fragile X Syndrome (FXS), a leading known cause of inherited intellectual developmental disability. Studies have shown… read more here.
Keywords: parent caregiver; cannabidiol; cbd; treatment fragile ... See more keywords