A systematic approach to reduce intraocular pressure for the treatment of glaucoma
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3285
Abstract: Glaucoma is the leading cause of irreversible blindness due to increased intraocular pressure (IOP) in the eye. We have developed a novel treatment option for glaucoma based on a real‐time IOP‐dependent nitric oxide synthase (NOS)… read more here.
Keywords: treatment glaucoma; glaucoma; intraocular pressure; systematic approach ... See more keywords
A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9614-7
Abstract: Extracellular nucleotides can regulate the production/drainage of the aqueous humor via activation of P2 receptors, thus affecting the intraocular pressure (IOP). We evaluated 5-OMe-UDP(α-B), 1A, a potent P2Y6-receptor agonist, for reducing IOP and treating glaucoma.… read more here.
Keywords: receptor; treatment glaucoma; p2y6 receptor; receptor agonist ... See more keywords
Drugs for the treatment of glaucoma: Targets, structure-activity relationships and clinical research.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113842
Abstract: Glaucoma is the third leading cause of blindness and impairment of vision worldwide, after refractive errors and cataracts. According to the survey, the number of people with glaucoma is more than 76 million, with projections… read more here.
Keywords: glaucoma; structure activity; treatment glaucoma; targets structure ... See more keywords
Development of novel therapeutics for the treatment of glaucoma based on actin-binding kinase inhibition – in silico approach
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05967a
Abstract: Actin-binding kinases are enzymes involved in the regulation of actin polymerization and microtubule disassembly. The inhibition of actin-binding kinases can be used in the treatment of glaucoma, since it relaxes the tissue, increases outflow facility,… read more here.
Keywords: treatment glaucoma; actin binding; binding kinase; inhibition ... See more keywords
Treatment of glaucoma and ocular hypertension using rho kinase inhibitors: patent evaluation of US2018244666 and US2018256595
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2019.1658743
Abstract: ABSTRACT Introduction: Glaucoma refers to a heterogeneous group of optic neuropathies characterized by an enhanced intraocular pressure (IOP). To date, there are six available different drug classes for the treatment of glaucoma and ocular hypertension:… read more here.
Keywords: treatment glaucoma; treatment; rho kinase; glaucoma ocular ... See more keywords
Assessment of thermal effects in a model of the human head implanted with a wireless active microvalve for the treatment of glaucoma creating a filtering bleb.
Sign Up to like & getrecommendations! Published in 2017 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/aa5dae
Abstract: A 3D anatomical computational model is developed to assess thermal effects due to exposure to the electromagnetic field required to power a new investigational active implantable microvalve for the treatment of glaucoma. Such a device,… read more here.
Keywords: electromagnetic field; thermal effects; microvalve treatment; filtering bleb ... See more keywords
An update on ripasudil for the treatment of glaucoma and ocular hypertension.
Sign Up to like & getrecommendations! Published in 2020 at "Drugs of today"
DOI: 10.1358/dot.2020.56.9.3178110
Abstract: Ripasudil (K-115) is a novel Rho-associated protein kinase (ROCK) inhibitor. The Rho-ROCK pathway regulates key downstream effectors involved in many cellular functions, in particular in the actin cytoskeleton activity. The clinical effects of ripasudil expected… read more here.
Keywords: ripasudil; ocular hypertension; treatment; treatment glaucoma ... See more keywords
The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222011077
Abstract: This review focuses on the clinical translation of preclinical studies, especially those that have used stem cells in the treatment of glaucoma, with an emphasis on optic nerve regeneration. The studies referred to in the… read more here.
Keywords: treatment glaucoma; stem; future stem; stem cells ... See more keywords
Study of minimally invasive radiofrequency ablation of the ciliary body for the treatment of glaucoma in rabbits
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10906
Abstract: The aim of the present study was to explore the safety and effectiveness of radiofrequency ablation (RFA) of the ciliary body for the treatment of glaucoma. A glaucoma model was established in New Zealand white… read more here.
Keywords: treatment glaucoma; ablation; treatment; ciliary body ... See more keywords
Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.355196
Abstract: Background and purpose: Prolonging the drug release can be a suitable approach to overcome the challenges related to topical ophthalmic administration of drugs especially the ones prescribed for chronic ailments. The sustained delivery of the… read more here.
Keywords: evaluation; polycaprolactone based; treatment glaucoma; timolol maleate ... See more keywords