Conventional Treatment of Glioblastoma Reveals Persistent CD44+ Subpopulations
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02004-2
Abstract: Glioblastoma (GBM) is the most frequent and devastating primary tumor of the central nervous system with a median survival of 12 to 15 months after diagnosis. GBM is highly difficult to treat due to its… read more here.
Keywords: conventional treatment; glioblastoma; treatment glioblastoma; gbm ... See more keywords
Frontiers in the treatment of glioblastoma: Past, present and emerging.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.01.012
Abstract: Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive research over the last several decades, the survival rates for GBM have not improved and prognosis remains poor. To date, only… read more here.
Keywords: glioblastoma past; glioblastoma; treatment glioblastoma; delivery ... See more keywords
Temozolomide for immunomodulation in the treatment of glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy072
Abstract: Temozolomide is the most widely used chemotherapy for patients with glioblastoma (GBM) despite the fact that approximately half of treated patients have temozolomide resistance and all patients eventually fail therapy. Due to the limited efficacy… read more here.
Keywords: treatment glioblastoma; immunomodulation treatment; treatment; temozolomide immunomodulation ... See more keywords
Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5861-4
Abstract: BackgroundA major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to therapy is commonly observed; however,… read more here.
Keywords: drug; heterogeneity; patient specific; treatment glioblastoma ... See more keywords
Anti-C1-inactivator treatment of glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26456
Abstract: Purpose Glioblastoma multiforme (GBM) or astrocytoma grade IV is the most common type of primary brain tumor in adults. In the present study, we investigate the role of the complement system in the glioblastoma situation… read more here.
Keywords: glioblastoma; treatment glioblastoma; treatment; inactivator treatment ... See more keywords
Efficacy of D,L-methadone in the treatment of glioblastoma in vitro
Sign Up to like & getrecommendations! Published in 2018 at "CNS Oncology"
DOI: 10.2217/cns-2018-0006
Abstract: Aim: Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM). Methods: We analyzed the μ-opioid receptor expression in a set of GBM cell lines and investigated the efficacy of D,L-methadone alone and… read more here.
Keywords: efficacy methadone; treatment glioblastoma; methadone treatment; treatment ... See more keywords
Network pharmacological analysis of active components of Xiaoliu decoction in the treatment of glioblastoma multiforme
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.940462
Abstract: Background: Glioblastoma multiforme (GBM) is the most aggressive primary nervous system brain tumor. There is still a lack of effective methods to control its progression and recurrence in clinical treatment. It is clinically found that… read more here.
Keywords: treatment glioblastoma; xld; glioblastoma multiforme; treatment ... See more keywords
Harnessing Microglia and Macrophages for the Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00506
Abstract: Glioblastoma multiforme (GBM) is the most malignant form of brain tumors, with a dismal prognosis. During the course of the disease, microglia and macrophages both infiltrate the tumor microenvironment and contribute considerably in glioma development.… read more here.
Keywords: harnessing microglia; microglia macrophages; physiology; treatment glioblastoma ... See more keywords
Photodynamic Therapy for the Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2019.00081
Abstract: Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the… read more here.
Keywords: photodynamic therapy; glioblastoma; treatment glioblastoma; therapy ... See more keywords
Viral Vectors as Gene Therapy Agents for Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123724
Abstract: Simple Summary Glioblastoma is the most malignant cancer of the brain and current therapeutic strategies are clearly inadequate. In addition to surgical intervention, conventional drugs and ratio-therapy, scientists are looking at approaches based on gene… read more here.
Keywords: viral vectors; treatment glioblastoma; gbm; gene therapy ... See more keywords
Design of Bio-Responsive Hyaluronic Acid–Doxorubicin Conjugates for the Local Treatment of Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010124
Abstract: Glioblastoma is an unmet clinical need. Local treatment strategies offer advantages, such as the possibility to bypass the blood–brain barrier, achieving high drug concentrations at the glioblastoma site, and consequently reducing systemic toxicity. In this… read more here.
Keywords: local treatment; dox; treatment glioblastoma; hyaluronic acid ... See more keywords