Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25453
Abstract: Viral remission after analytical treatment interruption (ATI), termed post‐treatment control, has been described in a small proportion of HIV‐positive patients. This phenomenon has been separately associated to both low levels of HIV‐1 proviral DNA as… read more here.
Keywords: viral rebound; treatment; treatment interruption; analytical treatment ... See more keywords
Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of virology"
DOI: 10.1128/jvi.01785-21
Abstract: The persistence of latent HIV-1-infected cells, named the latent reservoir, is the major barrier to HIV-1 eradication, and the formation and maintenance of latent reservoir might be exacerbated by activation of the immunoinhibitory pathway and… read more here.
Keywords: vaccination; blockade; treatment interruption; rhesus macaques ... See more keywords
Discordance between HIV-1 Population in Plasma at Rebound after Structured Treatment Interruption and Archived Provirus Population in Peripheral Blood Mononuclear Cells
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01353-22
Abstract: Even with effective ART, HIV-1 persists at undetectable levels and rebounds in individuals who stop treatment. Cellular and anatomical reservoirs ignite viral rebound upon treatment interruption, remaining one of the key obstacles for HIV-1 cure.… read more here.
Keywords: rebound; plasma; treatment; population ... See more keywords
Prevalence and predictive factors of tuberculosis treatment interruption in the Asia region: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Global Health"
DOI: 10.1136/bmjgh-2022-010592
Abstract: Introduction Tuberculosis (TB) treatment interruption remains a critical challenge leading to poor treatment outcomes. Two-thirds of global new TB cases are mostly contributed by Asian countries, prompting systematic analysis of predictors for treatment interruption due… read more here.
Keywords: prevalence; tuberculosis treatment; analysis; treatment ... See more keywords
Impact of Idelalisib Treatment Interruption with or without Dose Reduction on Outcomes in Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia
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DOI: 10.1182/blood-2019-124541
Abstract: Introduction: Idelalisib (IDELA) is the first-in-class PI3Kδ inhibitor and is approved as a monotherapy for relapsed or refractory (R/R) follicular lymphoma and in combination with rituximab for R/R chronic lymphocytic leukemia (CLL). We previously evaluated… read more here.
Keywords: treatment interruption; treatment; research funding; interruption ... See more keywords
Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease
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DOI: 10.1371/journal.pone.0185033
Abstract: Background Etiological treatment of Chagas disease in chronic asymptomatic patients is still in debate and the adverse effects of traditional drugs are one of the main concerns in clinical practice. This study evaluated retrospectively the… read more here.
Keywords: risk factors; treatment; chagas disease; treatment interruption ... See more keywords
Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019
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DOI: 10.1371/journal.pone.0248820
Abstract: Tuberculosis (TB) is the leading cause of mortality as a single infectious agent globally with increasing numbers of case notification in developing countries. This study seeks to investigate the clinical and socio-demographic factors of time… read more here.
Keywords: county 2016; treatment interruption; treatment; patients kiambu ... See more keywords
Drug Non-Adherence And Reasons Among Multidrug-Resistant Tuberculosis Patients In Guizhou, China: A Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2019 at "Patient preference and adherence"
DOI: 10.2147/ppa.s219920
Abstract: Purpose Treatment interruption and incorrect dosage for measuring drug non-adherence have seldom been studied in multidrug-resistant tuberculosis (MDR-TB) treatment. This study aimed to 1) estimate the overall and drug-specific incidence of short (≤14 days) and… read more here.
Keywords: interruption; drug; study; adherence ... See more keywords
Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption
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DOI: 10.3390/ijms24021031
Abstract: Lately, the interest in long non-coding RNAs (lncRNAs) as potential drug targets and predictive markers in the context of HIV-1 has peaked, but their in vivo expression and regulation remains largely unexplored. Therefore, the present… read more here.
Keywords: hiv; lncrna expression; expression; treatment interruption ... See more keywords
Causes of HIV Treatment Interruption during the Last 20 Years: A Multi-Cohort Real-Life Study
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DOI: 10.3390/v15030720
Abstract: In the last years, many antiretroviral drugs (ART) have been developed with increased efficacy. Nowadays, the main reasons for treatment switches are adverse events, proactive strategy or simplification. We conducted a retrospective cohort study to… read more here.
Keywords: last years; cohort; interruption last; interruption ... See more keywords
Predictors of SIV recrudescence following antiretroviral treatment interruption
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.49022
Abstract: There is currently a need for proxy measures of the HIV rebound competent reservoir (RCR) that can predict viral rebound after combined antiretroviral treatment (cART) interruption. In this study, macaques infected with a barcoded SIVmac239… read more here.
Keywords: interruption; treatment; treatment interruption; siv recrudescence ... See more keywords