Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
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DOI: 10.1002/jia2.25453
Abstract: Viral remission after analytical treatment interruption (ATI), termed post‐treatment control, has been described in a small proportion of HIV‐positive patients. This phenomenon has been separately associated to both low levels of HIV‐1 proviral DNA as… read more here.
Keywords: viral rebound; treatment; treatment interruption; analytical treatment ... See more keywords
Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, implementation and early clinical data
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DOI: 10.1002/jia2.26495
Abstract: Antiretroviral therapy (ART) prevents and treats, but does not eradicate, HIV. Early ART initiation is associated with post‐ART virologic control, particularly among African women, and anti‐HIV‐1 broadly neutralizing antibodies (bnAbs) may modulate immune responses to… read more here.
Keywords: among women; treatment interruption; interruption among; analytical treatment ... See more keywords
Implications of therapy interruption on monthly migraine days and modified migraine disability assessment in patients treated with erenumab for chronic and episodic migraine: SQUARE study interim results
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DOI: 10.1007/s00415-024-12470-6
Abstract: There are limited real-world data in Switzerland examining the impact of erenumab, a fully human IgG2 monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor, on migraine-related quality of life. This 18-month interim analysis of… read more here.
Keywords: interruption; treatment interruption; square study; migraine ... See more keywords
Supporting re-engagement with HIV services after treatment interruption in South Africa: a mixed method program evaluation of MSF’s Welcome Service
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DOI: 10.1038/s41598-024-57774-9
Abstract: Psychosocial challenges impact patients’ ability to remain on antiretroviral therapy lifelong, magnified by disorganized health-systems and healthcare worker (HCW) attitudes. To address this, Médecins Sans Frontières and the Department of Health developed the Welcome Service… read more here.
Keywords: engagement hiv; treatment interruption; south africa; service ... See more keywords
Triggers of treatment interruption and resumption among individuals with type 2 diabetes: a narrative cross-sectional qualitative study
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DOI: 10.1080/17482631.2025.2496181
Abstract: ABSTRACT Purpose Treatment interruption and resumption are common among people with type 2 diabetes mellitus (T2D), but the triggers of resumption, according to the reasons for interruption, remain underexplored. This study examined patterns of treatment… read more here.
Keywords: treatment; treatment interruption; resumption; interruption resumption ... See more keywords
Exacerbated AIDS progression by PD-1 blockade during therapeutic vaccination in chronically SIV-infected rhesus macaques after ART treatment interruption.
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DOI: 10.1128/jvi.01785-21
Abstract: The persistence of latent HIV-1-infected cells, named the latent reservoir, is the major barrier to HIV-1 eradication, and the formation and maintenance of latent reservoir might be exacerbated by activation of the immunoinhibitory pathway and… read more here.
Keywords: vaccination; blockade; treatment interruption; rhesus macaques ... See more keywords
Discordance between HIV-1 Population in Plasma at Rebound after Structured Treatment Interruption and Archived Provirus Population in Peripheral Blood Mononuclear Cells
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DOI: 10.1128/spectrum.01353-22
Abstract: Even with effective ART, HIV-1 persists at undetectable levels and rebounds in individuals who stop treatment. Cellular and anatomical reservoirs ignite viral rebound upon treatment interruption, remaining one of the key obstacles for HIV-1 cure.… read more here.
Keywords: rebound; plasma; treatment; population ... See more keywords
Prevalence and predictive factors of tuberculosis treatment interruption in the Asia region: a systematic review and meta-analysis
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DOI: 10.1136/bmjgh-2022-010592
Abstract: Introduction Tuberculosis (TB) treatment interruption remains a critical challenge leading to poor treatment outcomes. Two-thirds of global new TB cases are mostly contributed by Asian countries, prompting systematic analysis of predictors for treatment interruption due… read more here.
Keywords: prevalence; tuberculosis treatment; analysis; treatment ... See more keywords
Impact of Idelalisib Treatment Interruption with or without Dose Reduction on Outcomes in Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia
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DOI: 10.1182/blood-2019-124541
Abstract: Introduction: Idelalisib (IDELA) is the first-in-class PI3Kδ inhibitor and is approved as a monotherapy for relapsed or refractory (R/R) follicular lymphoma and in combination with rituximab for R/R chronic lymphocytic leukemia (CLL). We previously evaluated… read more here.
Keywords: treatment interruption; treatment; research funding; interruption ... See more keywords
Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease
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DOI: 10.1371/journal.pone.0185033
Abstract: Background Etiological treatment of Chagas disease in chronic asymptomatic patients is still in debate and the adverse effects of traditional drugs are one of the main concerns in clinical practice. This study evaluated retrospectively the… read more here.
Keywords: risk factors; treatment; chagas disease; treatment interruption ... See more keywords
Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019
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DOI: 10.1371/journal.pone.0248820
Abstract: Tuberculosis (TB) is the leading cause of mortality as a single infectious agent globally with increasing numbers of case notification in developing countries. This study seeks to investigate the clinical and socio-demographic factors of time… read more here.
Keywords: county 2016; treatment interruption; treatment; patients kiambu ... See more keywords