Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.019
Abstract: The most effective medicines available for the treatment of leishmaniasis, a life-threatening disease, exhibit serious toxicological issues. To achieve better therapeutic efficiency while decreasing toxicity associated with amphotericin B (AmB), water-soluble dextrin-AmB (Dex-AmB) formulations were… read more here.
Keywords: treatment leishmaniasis; dex amb; dextrin; dex ... See more keywords
A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00632
Abstract: Leishmaniasis is an infectious disease responsible for a huge rate of morbidity and mortality in humans. Chemotherapy consists of the use of pentavalent antimonial, amphotericin B, pentamidine, miltefosine, and paromomycin. However, these drugs are associated… read more here.
Keywords: treatment leishmaniasis; carrying nanosystems; drug; drug carrying ... See more keywords
Effectiveness in vivo and in vitro of Polymeric Nanoparticles as a Drug Release System in the Treatment of Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230120163543
Abstract: Leishmaniasis is a neglected disease caused by the parasite of the genus Leishmania. Current treatment regimens are obsolete and cause several side effects, promoting poor patient compliance, in addition to the vast majority already having… read more here.
Keywords: treatment leishmaniasis; polymeric nanoparticles; drug release; treatment ... See more keywords
The Potential of Traditional Knowledge to Develop Effective Medicines for the Treatment of Leishmaniasis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.690432
Abstract: Leishmaniasis is a neglected tropical disease that affects people living in tropical and subtropical areas of the world. There are few therapeutic options for treating this infectious disease, and available drugs induce severe side effects… read more here.
Keywords: traditional knowledge; treat leishmaniasis; treatment leishmaniasis; leishmaniasis ... See more keywords
In Vitro Evaluation of Aerosol Therapy with Pentamidine-Loaded Liposomes Coated with Chondroitin Sulfate or Heparin for the Treatment of Leishmaniasis
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041163
Abstract: The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited by severe adverse effects, including diabetes, severe hypoglycemia, myocarditis and renal toxicity. We sought to test the potential… read more here.
Keywords: pentamidine; aerosol therapy; heparin; treatment leishmaniasis ... See more keywords