4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00620
Abstract: The mechanistic target of rapamycin (mTOR) pathway is hyperactivated in cancer and neurological disorders. Rapalogs and mTOR kinase inhibitors (TORKi) have recently been applied to alleviate epileptic seizures in tuberous sclerosis complex (TSC). Herein, we… read more here.
Keywords: brain penetrant; pqr626; mtor; treatment neurological ... See more keywords
Lipid-based nanoformulations in the treatment of neurological disorders
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2020.1726942
Abstract: Abstract The neurological disorders affect millions of people worldwide, and are bracketed as the foremost basis of disability-adjusted life years (DALYs). The treatment options are symptomatic and often the movement of drugs is restricted by… read more here.
Keywords: based nanoformulations; lipid based; nanoformulations treatment; treatment neurological ... See more keywords
Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2066334
Abstract: ABSTRACT RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently… read more here.
Keywords: therapeutics treatment; system; disease; rna therapeutics ... See more keywords
An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of NeuroEngineering and Rehabilitation"
DOI: 10.1186/s12984-018-0349-z
Abstract: Dynamic feedback based closed-loop medical devices offer a number of advantages for treatment of heterogeneous neurological conditions. Closed-loop devices integrate a level of neurobiological feedback, which allows for real-time adjustments to be made with the… read more here.
Keywords: treatment; loop treatment; investigation closed; feedback ... See more keywords
Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1159806
Abstract: Background Silymarin is a polyphenolic flavonoid complex extricated from dried fruits and seeds of the plant Silybum marianum L. Chemically, it is a mixture of flavonolignan complexes consisting of silybin, isosilybin, silychristin, silydianin, a minor… read more here.
Keywords: silymarin treatment; neurological disorders; treatment neurological; treatment ... See more keywords
Antioxidant Thymoquinone and Its Potential in the Treatment of Neurological Diseases
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DOI: 10.3390/antiox12020433
Abstract: Oxidative stress is one of the main pathogenic factors of neuron damage in neurodegenerative processes; this makes it an important therapeutic target to which the action of neuroprotectors should be directed. One of these drugs… read more here.
Keywords: potential treatment; thymoquinone potential; neurological diseases; treatment neurological ... See more keywords
Combined Cell Therapy in the Treatment of Neurological Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8120613
Abstract: Cell therapy of neurological diseases is gaining momentum. Various types of stem/progenitor cells and their derivatives have shown positive therapeutic results in animal models of neurological disorders and in clinical trials. Each tested cell type… read more here.
Keywords: cell therapy; neurological disorders; treatment neurological; combined cell ... See more keywords
Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders
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DOI: 10.3390/nano12132140
Abstract: Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to the World Health Organization (WHO), neurological disorders are one of the main causes of mortality worldwide. Neurological disorders include Alzheimer’s… read more here.
Keywords: various types; disease; neurological disorders; brain ... See more keywords
Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
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DOI: 10.3390/ph15040408
Abstract: Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those with memory and cognitive impairment. TQ protects brain cells from oxidative stress, which is… read more here.
Keywords: thymoquinone review; review potential; potential treatment; neurological diseases ... See more keywords