Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01732
Abstract: Platelet-derived growth factor receptors (PDGFRs) are now considered promising targets for the treatment of osteosarcoma. Herein, the design, synthesis, and structure-activity relationships (SAR) of novel pyrimidine-2,4-diamine derivatives that selectively inhibit PDGFRα/β kinases have been studied.… read more here.
Keywords: treatment osteosarcoma; pdgfr; growth factor; derived growth ... See more keywords
Successful Treatment of Osteosarcoma Without Methotrexate in a 13-Year-Old Boy With Down Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000001212
Abstract: Osteosarcoma is the most common primary bone tumor in children, and only 1 article in the literature describes a case of osteosarcoma in a patient with Down syndrome. Although osteosarcoma is generally treated with chemotherapy… read more here.
Keywords: successful treatment; without methotrexate; treatment osteosarcoma; osteosarcoma ... See more keywords
Innovative approaches for treatment of osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702211067718
Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumor, which usually occurs in children and adolescents. It is generally a high-grade malignancy presenting with extreme metastases to the lungs or other bones. The etiology… read more here.
Keywords: treatment osteosarcoma; medicine; treatment; biology ... See more keywords
The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study
Sign Up to like & getrecommendations! Published in 2018 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-018-2245-x
Abstract: BackgroundSurvival and reconstruction constitute important challenges in multimodal treatment of osteosarcoma of the proximal tibia. The purpose of this study was to assess the efficacy and prognosis of neoadjuvant chemotherapy and custom-designed endoprosthetic arthroplasty.MethodsA total… read more here.
Keywords: multidisciplinary treatment; osteosarcoma proximal; treatment osteosarcoma; proximal tibia ... See more keywords
Recent Advances in Nanoplatforms for the Treatment of Osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.805978
Abstract: Osteosarcoma (OS) is the most common primary bone tumor in children and young people. Traditional surgical excision combined with chemotherapy presents many limitations, such as resistance and systemic side effects of chemotherapy drugs, postoperative recurrence,… read more here.
Keywords: advances nanoplatforms; treatment osteosarcoma; bone; nanoplatforms treatment ... See more keywords
NOTCH Signaling in Osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45030146
Abstract: The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and… read more here.
Keywords: notch signaling; treatment osteosarcoma; notch pathway; notch ... See more keywords
Treatment of osteosarcoma around the knee in skeletally immature patients
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.6903
Abstract: Limb sparing surgery in growing young patients with malignant tumors is difficult as invasion of the physis by the tumor or surgical resection through the metaphysis may cause significant limb discrepancy following surgery. At present,… read more here.
Keywords: osteosarcoma around; around knee; treatment osteosarcoma; tumor ... See more keywords