Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.
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DOI: 10.1021/acs.jmedchem.2c01624
Abstract: Highly selective dopamine D3 receptor (D3R) partial agonists/antagonists have been developed for the treatment of psychostimulant use disorders (PSUD). However, none have reached the clinic due to insufficient potency/efficacy or potential cardiotoxicity. Cariprazine, an FDA-approved… read more here.
Keywords: partial agonists; dopamine receptor; agonists antagonists; treatment psychostimulant ... See more keywords