Anakinra treatment for refractory cerebral autoinflammatory responses
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51500
Abstract: Refractory cerebral autoinflammatory–autoimmune diseases are often associated with dysregulated innate immunity and are targeted by anakinra, an interleukin‐1 receptor antagonist. We analyzed the therapeutic effect of anakinra in refractory cerebral autoinflammatory response (CAIR) at a… read more here.
Keywords: autoinflammatory responses; anakinra treatment; refractory cerebral; cerebral autoinflammatory ... See more keywords
Lymphaticovenous anastomosis for treatment of refractory chylous ascites: A case report.
Sign Up to like & getrecommendations! Published in 2023 at "Microsurgery"
DOI: 10.1002/micr.31042
Abstract: Chylous ascites, the leakage of lymphatic fluid into the abdominal cavity caused by lymphatic fluid stasis or lymphatic vessel damage, can be treated by lymphaticovenous anastomosis (LVA). We report rarely performed abdominal LVA to treat… read more here.
Keywords: chylous ascites; treatment refractory; anastomosis; refractory chylous ... See more keywords
[Results of vagus nerve stimulator implantation in children and adolescents with treatment-refractory epilepsy].
Sign Up to like & getrecommendations! Published in 2022 at "HNO"
DOI: 10.1007/s00106-022-01164-y
Abstract: Vagus nerve stimulation (VNS) is a therapeutic procedure that can be applied in a palliative setting in patients with treatment-refractory epilepsy who are not suitable for epilepsy surgery. The mechanism of action of VNS is currently not… read more here.
Keywords: nerve stimulator; epilepsy; treatment refractory; vagus nerve ... See more keywords
Treatment of refractory adult onset Still’s disease with tocilizumab—a single centre experience and literature review
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology International"
DOI: 10.1007/s00296-020-04622-4
Abstract: Adult-onset Still's disease (AOSD) is defined as a systemic inflammatory disorder of unknown aetiology and is classified as a multigene autoinflammatory disease. Treatment of AOSD still remains mostly empirical with nonsteroidal anti-inflammatory drugs, glucocorticoids and… read more here.
Keywords: onset still; adult onset; aosd; treatment ... See more keywords
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica"
DOI: 10.1007/s00401-024-02736-8
Abstract: Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory behavior are the rare subset that progress after surgery, conventional medical therapies, and an initial course of radiation and are characterized by unrelenting growth and/or metastatic dissemination. Two… read more here.
Keywords: aggressive treatment; refractory behavior; treatment; treatment refractory ... See more keywords
The concept, intention, and evaluation of the term treatment-refractory meningioma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-025-05154-2
Abstract: Treatment-refractory meningioma is a widely used term but lacks standardized criteria, impairing research comparability and treatment evaluation. The aim of this study was to assess the heterogeneity of patient populations labeled as treatment-refractory and to… read more here.
Keywords: treatment refractory; refractory meningioma; treatment; term ... See more keywords
The Role of Plasma Exchange in the Treatment of Refractory Autoimmune Neurological Diseases: a Narrative Review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-021-10004-9
Abstract: Autoimmune neurological disorders are commonly treated with immunosuppressive therapy. In patients with refractory conditions, standard immunosuppression is often insufficient for complete recovery or to prevent relapses. These patients rely on other treatments to manage their… read more here.
Keywords: refractory; refractory autoimmune; plasma exchange; autoimmune neurological ... See more keywords
Effectiveness and safety of rituximab for the treatment of refractory systemic sclerosis associated calcinosis: A case series and systematic review of the literature.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.10.006
Abstract: OBJECTIVE To analyze the effectiveness and safety of rituximab (RTX) for the treatment of refractory systemic sclerosis (SSc)-associated calcinosis. METHODS We undertook an observational study of patients with this complication treated with 1 or more… read more here.
Keywords: effectiveness safety; treatment refractory; rtx; safety rituximab ... See more keywords
Gamma Ventral Capsulotomy in Intractable Obsessive-Compulsive Disorder
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.034
Abstract: BACKGROUND Despite the development of effective pharmacologic and cognitive behavioral treatments for obsessive-compulsive disorder (OCD), some patients continue to be treatment-refractory and severely impaired. Fiber tracts connecting orbitofrontal and dorsal anterior cingulate cortex with subcortical… read more here.
Keywords: ventral capsulotomy; treatment refractory; compulsive disorder; obsessive compulsive ... See more keywords
Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2021.108779
Abstract: CTLA4-haploinsufficiency is a complex disease of immune dysregulation presenting with a broad spectrum of clinical manifestations. CTLA4-Fc fusion proteins such as abatacept have been described to alleviate immune dysregulation in several adult cases of CTLA4-haploinsufficiency.… read more here.
Keywords: abatacept treatment; ctla4 haploinsufficiency; treatment refractory; haploinsufficiency ... See more keywords
Successful treatment of refractory folliculitis decalvans with apremilast
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DOI: 10.1016/j.jdcr.2020.08.019
Abstract: IL: interleukin INTRODUCTION Folliculitis decalvans is a rare neutrophilic inflammation of the scalp, characterized by painful follicular papules, pustules, crusting, and tufting of hairs. It results in the destruction of hair follicles and finally in… read more here.
Keywords: folliculitis decalvans; successful treatment; refractory folliculitis; treatment refractory ... See more keywords