Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9323
Abstract: Sequential, multiple assignment, randomized trials (SMARTs) compare sequences of treatment decision rules called dynamic treatment regimes (DTRs). In particular, the Adaptive Treatment for Alcohol and Cocaine Dependence (ENGAGE) SMART aimed to determine the best DTRs… read more here.
Keywords: set best; treatment regimes; sample size; dynamic treatment ... See more keywords
Using dynamic treatment regimes to understand erythropoietin-stimulating agent hyporesponsiveness
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-3948-9
Abstract: BackgroundErythropoietin-stimulating agent hyporesponsiveness (ESAH) is associated with increased cardiovascular mortality in patients with end-stage renal disease (ESRD) on hemodialysis. Dynamic treatment regimes (DTR), a clinical decision support (CDS) tool that guides the prescription of specific… read more here.
Keywords: treatment regimes; dynamic treatment; treatment; stimulating agent ... See more keywords
Effect of different oral oxytetracycline treatment regimes on selection of antimicrobial resistant coliforms in nursery pigs.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.07.005
Abstract: A major concern derived from using antimicrobials in pig production is the development of resistance. This study aimed to assess the impact of selected combinations of oral dose and duration of treatment with oxytetracycline (OTC)… read more here.
Keywords: treatment; proportion tet; nursery pigs; tet ... See more keywords
Quantile-Optimal Treatment Regimes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Statistical Association"
DOI: 10.1080/01621459.2017.1330204
Abstract: ABSTRACT Finding the optimal treatment regime (or a series of sequential treatment regimes) based on individual characteristics has important applications in areas such as precision medicine, government policies, and active labor market interventions. In the… read more here.
Keywords: treatment; quantile optimal; optimal treatment; treatment regime ... See more keywords
Estimation for optimal treatment regimes with survival data under semiparametric model
Sign Up to like & getrecommendations! Published in 2020 at "Communications in Statistics - Theory and Methods"
DOI: 10.1080/03610926.2020.1808686
Abstract: Abstract In this paper, we consider a semiparametric model to find the optimal treatment regimes. A-learning type equation method is proposed to construct a doubly robust estimating equation for the parameters of interest in the… read more here.
Keywords: optimal treatment; estimation optimal; semiparametric model; treatment regimes ... See more keywords
Semiparametric Bayesian inference for optimal dynamic treatment regimes via dynamic marginal structural models.
Sign Up to like & getrecommendations! Published in 2022 at "Biostatistics"
DOI: 10.1093/biostatistics/kxac007
Abstract: Considerable statistical work done on dynamic treatment regimes (DTRs) is in the frequentist paradigm, but Bayesian methods may have much to offer in this setting as they allow for the appropriate representation and propagation of… read more here.
Keywords: treatment regimes; dynamic treatment; bayesian inference; structural models ... See more keywords
Antibiotic Treatment Regimes as a Driver of the Global Population Dynamics of a Major Gonorrhea Lineage
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DOI: 10.1093/molbev/msaa282
Abstract: Abstract The Neisseria gonorrhoeae multilocus sequence type (ST) 1901 is among the lineages most commonly associated with treatment failure. Here, we analyze a global collection of ST-1901 genomes to shed light on the emergence and… read more here.
Keywords: treatment regimes; treatment; driver global; regimes driver ... See more keywords
Learning and Assessing Optimal Dynamic Treatment Regimes Through Cooperative Imitation Learning
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DOI: 10.1109/access.2022.3193494
Abstract: Dynamic Treatment Regimes (DTRs) are sets of sequential decision rules that can be adapted over time to treat patients with a specific pathology. DTR consists of alternative treatment paths and any of these treatments can… read more here.
Keywords: treatment regimes; dynamic treatment; imitation learning; treatment ... See more keywords
Resampling-based confidence intervals for model-free robust inference on optimal treatment regimes.
Sign Up to like & getrecommendations! Published in 2020 at "Biometrics"
DOI: 10.1111/biom.13337
Abstract: We propose a new procedure for inference on optimal treatment regimes in the model-free setting, which does not require to specify an outcome regression model. Existing model-free estimators for optimal treatment regimes are usually not… read more here.
Keywords: treatment; inference optimal; optimal treatment; treatment regimes ... See more keywords
Imputation-based Q-learning for optimizing dynamic treatment regimes with right-censored survival outcome.
Sign Up to like & getrecommendations! Published in 2023 at "Biometrics"
DOI: 10.1111/biom.13872
Abstract: Q-learning has been one of the most commonly used methods for optimizing dynamic treatment regimes (DTRs) in multi-stage decision making. Right-censored survival outcome poses a significant challenge to Q-Learning due to its reliance on parametric… read more here.
Keywords: right censored; treatment regimes; dynamic treatment; imputation ... See more keywords