Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2102477
Abstract: ABSTRACT Introduction It is now well established that sepsis induces a state of acquired immunosuppression, with an increased risk of secondary infections that contributes to patients’ worsening. Thus, tackling sepsis-induced immunosuppression represents a promising perspective.… read more here.
Keywords: sepsis; checkpoint inhibitors; immune checkpoint; inhibitors treatment ... See more keywords
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15579
Abstract: Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive, and there are no treatments that reverse the… read more here.
Keywords: megadose vitamin; sepsis; dysfunction; sepsis covid ... See more keywords
Safety and efficacy of human umbilical cord mesenchymal stem cells for the treatment of sepsis induced by pneumonia: study protocol for a single-centre, randomised single-blind parallel group trial
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-058444
Abstract: Introduction Sepsis is a life-threatening organ disorder caused by a dysregulated inflammatory response to infection with no effective treatment options exist thus far. Therefore, novel therapeutic methods are urgently advocated for decreasing the high mortality… read more here.
Keywords: sepsis; trial; efficacy; treatment sepsis ... See more keywords
A Standardized Step-by-Step Approach for the Diagnosis and Treatment of Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Intensive Care Medicine"
DOI: 10.1177/08850666221085181
Abstract: Sepsis is the major culprit of death among critically ill patients who are hospitalized in intensive care units (ICUs). Although sepsis-related mortality is steadily declining year-by-year due to the continuous understanding of the pathophysiological mechanism… read more here.
Keywords: sepsis; treatment sepsis; approach; standardized step ... See more keywords
Protein Phosphorylation Mechanism of Mesenchymal Stem Cells in the Treatment of Sepsis: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524023666221020124204
Abstract: BACKGROUND The severity and mortality of sepsis is related to excessive inflammation and cytokine storm. Nevertheless, little is known about why sepsis has a significant increase in proinflammatory cytokine production, which leads to more severe… read more here.
Keywords: sepsis; mesenchymal stem; mechanism; treatment sepsis ... See more keywords
Precision immunotherapy treatment for sepsis.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202304_31948
Abstract: In intensive care units, sepsis has traditionally been the disease with the highest mortality rate and the highest cost of care. Now, the attention to sepsis is not only the initial systemic inflammatory response, but… read more here.
Keywords: sepsis; immunotherapy treatment; immunotherapy; infection ... See more keywords
Traditional Chinese medicine for treatment of sepsis and related multi-organ injury
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1003658
Abstract: Sepsis is a common but critical illness in patients admitted to the intensive care unit and is associated with high mortality. Although there are many treatments for sepsis, specific and effective therapies are still lacking.… read more here.
Keywords: sepsis; chinese medicine; treatment sepsis; medicine ... See more keywords
Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222011078
Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%.… read more here.
Keywords: sepsis; herbal medicines; treatment sepsis; chinese herbal ... See more keywords
[Effect of CRRT on the clearance of antibiotics in the treatment of sepsis].
Sign Up to like & getrecommendations! Published in 2017 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.issn.2095-4352.2017.07.019
Abstract: OBJECTIVE Sepsis should be defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection. Continuous renal replacement therapy (CRRT) is one of the methods for the clinical treatment of sepsis. For patients… read more here.
Keywords: sepsis; effect crrt; treatment; treatment sepsis ... See more keywords