The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling.
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DOI: 10.1021/acsinfecdis.7b00046
Abstract: Host-directed therapeutics have the potential to combat the global tuberculosis pandemic. We previously identified gefitinib, an inhibitor of EGFR, as a potential host-targeted therapeutic effective against Mycobacterium tuberculosis infection of macrophages and mice. Here we… read more here.
Keywords: tuberculosis; gefitinib treatment; mycobacterium tuberculosis; treatment tuberculosis ... See more keywords
Intensified antibiotic treatment of tuberculosis meningitis
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DOI: 10.1080/17512433.2019.1552831
Abstract: ABSTRACT Introduction: Meningitis is the most severe manifestation of tuberculosis, resulting in death or disability in over 50% of those affected, with even higher morbidity and mortality among patients with HIV or drug resistance. Antimicrobial… read more here.
Keywords: meningitis; treatment tuberculosis; treatment; antibiotic treatment ... See more keywords
Diagnosis and treatment of tuberculosis in adults with HIV
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DOI: 10.1097/md.0000000000030405
Abstract: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), continues to pose a major public health problem and is the leading cause of mortality in people infected with human immunodeficiency virus (HIV). HIV infection greatly increases… read more here.
Keywords: tuberculosis; diagnosis treatment; treatment; tuberculosis adults ... See more keywords
Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients
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DOI: 10.3390/ijms23073860
Abstract: Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the… read more here.
Keywords: tuberculosis patients; impact vitamin; tuberculosis; treatment tuberculosis ... See more keywords
Dose of Isoniazid in Renal Disease for Treatment of Tuberculosis
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DOI: 10.4103/aian.aian_729_21
Abstract: I read with interest the paper on Isoniazid induced cerebellitis by Shah VS and Sardana V in the recent AIAN journal.[1] The authors described a patient with chronic renal disease, on 375 mg of isoniazid… read more here.
Keywords: treatment tuberculosis; renal disease; disease; dose isoniazid ... See more keywords