Molecular cloning and characterization of NPC1L1 in the Chinese tree shrew (Tupaia belangeri chinensis).
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06829-5
Abstract: BACKGROUND The Niemann-Pick C1-Like 1 protein, a multi-transmembrane domain molecule, is critical for intestinal cholesterol absorption, and is the entry factor for hepatitis C virus (HCV). The Chinese tree shrew (Tupaia belangeri chinensis) is closer… read more here.
Keywords: tupaia belangeri; tree shrew; tree; chinese tree ... See more keywords
The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00106-3
Abstract: As a universal pathogen leading to neonatal defects and transplant failure, human cytomegalovirus (HCMV) has strict species specificity and this has prevented the development of a suitable animal model for the pathogenesis study. The mechanism… read more here.
Keywords: susceptibility primary; dermis fibroblasts; tree shrew; chinese tree ... See more keywords
Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-018-0212-z
Abstract: The striatum and globus pallidus are principal nuclei of the basal ganglia. Nissl- and acetylcholinesterase-stained sections of the tree shrew brain showed the neuroanatomical features of the caudate nucleus (Cd), internal capsule (ic), putamen (Pu),… read more here.
Keywords: striatum globus; tree shrew; globus pallidus; atlas striatum ... See more keywords
Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104307
Abstract: DNA damage inducible transcript 3 (DDIT3, also known as CHOP) belongs to the CCAAT/enhancer-binding protein (C/EBP) family and plays an essential role in endoplasmic reticulum stress. Here, we characterized the potential role of the Chinese… read more here.
Keywords: dna damage; tree shrew; damage inducible; role ... See more keywords
Detection and characterization of tree shrew retinal venous pulsations: An animal model to study human retinal venous pulsations.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.06.003
Abstract: Spontaneous retinal venous pulsations (SRVPs), pulsations of branches of the central retinal vein, are affected by intraocular pressure (IOP) and intracranial pressure (ICP) and thus convey potentially-useful information about ICP. However, the exact relationship between… read more here.
Keywords: icp; animal model; tree shrew; venous pulsations ... See more keywords
Conserved structure and function of chemokine CXCL8 between Chinese tree shrews and humans.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.025
Abstract: Chemokines represent a superfamily of small secretion proteins that functionally mediate immune cell transmigration in normal or inflammatory conditions. Although anatomic and polygenetic evidence suggests that tree shrews are primate-like species, understanding of the structure… read more here.
Keywords: shrews humans; tree shrews; tree shrew; chemokine cxcl8 ... See more keywords
A compressed hierarchy for visual form processing in the tree shrew
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-09441-w
Abstract: Our knowledge of the brain processes that govern vision is largely derived from studying primates, whose hierarchically organized visual system1 inspired the architecture of deep neural networks2. This raises questions about the universality of such… read more here.
Keywords: tree shrew; form processing; visual form;
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2141153
Abstract: Abstract Tree shrews have high phylogenetic affinity to humans and are used in various fields of biomedical research, especially hepatitis virus infection; however, cytochromes P450 (P450s or CYPs) have not been investigated in this species.… read more here.
Keywords: tree shrew; pig cyp2b6b; cyp2b6; cyp2b6 pig ... See more keywords
Cross-Species Insights from Single-Nucleus Sequencing Highlight Aging-Related Hippocampal Features in Tree Shrew
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaf020
Abstract: Abstract The tree shrew brain has garnered considerable attention due to its remarkable similarities to human brain. However, the cellular composition and genetic signatures of tree shrew hippocampus across postnatal life remain poorly characterized. Here,… read more here.
Keywords: tree shrew; single nucleus; cross species; shrew hippocampus ... See more keywords
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00020-21
Abstract: The development of animal models is critical for studying human diseases and their pathogenesis and for evaluating drug and vaccine efficacy. For improved AIDS research, the ideal animal model of HIV-1 infection should be a… read more here.
Keywords: tree shrew; hiv; human cd4; replication ... See more keywords
An Investigation of the Mechanisms of Radiation-Induced Muscle Injury in a Tree Shrew (Tupaia belangeri) Model
Sign Up to like & getrecommendations! Published in 2022 at "Dose-Response"
DOI: 10.1177/15593258221082878
Abstract: Background Animal models suitable for investigating mechanisms behind radiation-induced muscle injury are lacking. We developed a tree shrew model of such injury and investigated pathological changes and mechanisms. Methods Animals were divided into control (n… read more here.
Keywords: tree shrew; muscle injury; radiation; injury ... See more keywords