A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747359
Abstract: Signaling through the T cell receptor (TCR) regulates T cell homeostasis and effector functions. However, a full accounting of the TCR‐coupled signaling networks and how their interplay determines specific functional outcomes remains elusive. Of particular… read more here.
Keywords: treg; regulatory cells; cell receptor; cell ... See more keywords
Regulatory T‐cell development in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149358
Abstract: Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the development of autoimmune diseases. However, Treg cells are abundant in tumors and suppress antitumor immunity, contributing to tumor development and growth. Thus, the… read more here.
Keywords: cell; treg; treg cells; development ... See more keywords
Neuropilin‐1 is present on Foxp3+ T regulatory cell‐derived small extracellular vesicles and mediates immunity against skin transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12237
Abstract: Abstract Among the mechanisms of suppression that T regulatory (Treg) cells exert to control the immune responses, the secretion of small extracellular vesicles (sEV) has been recently proposed as a novel contact‐independent immunomodulatory mechanism. Previous… read more here.
Keywords: treg; extracellular vesicles; treg cells; transplantation ... See more keywords
Treg Cells and Epigenetic Regulation.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-6407-9_6
Abstract: The discovery of the epigenetic regulation of Treg cells, a cell population with fundamental immunoregulatory properties, has shed considerable insights into an understanding of the role of these cells in health and disease. Research over… read more here.
Keywords: cells epigenetic; treg cells; regulation treg; epigenetic regulation ... See more keywords
Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCMin/+ mice
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02540-9
Abstract: The presence of activated T cells in colorectal cancer tissues is a strong predictor of patient survival. Our previous studies have shown that regulatory T cells (Treg) are able to reduce T cell transendothelial migration… read more here.
Keywords: tcr cd8; cells intestinal; cd8 cells; intestinal tumors ... See more keywords
Non-lupus full-house nephropathy—immune dysregulation as a rare cause of pediatric nephrotic syndrome: Answers
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Nephrology"
DOI: 10.1007/s00467-021-05378-0
Abstract: Based on the synchroneity of severe infections, multiple autoimmune disorders, atopic dermatitis, chronic diarrhoea and insufficient weight gain, the “immunodysregulation, polyendocrinopathy, enteropathy, X-linked” (IPEX) or IPEXlike syndrome was first suspected at the age of 8… read more here.
Keywords: syndrome; lupus full; treg; full house ... See more keywords
Adoptive Induced Antigen-Specific Treg Cells Reverse Inflammation in Collagen-Induced Arthritis Mouse Model
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0704-4
Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease that may cause bone damage and worsening disability. Manipulating antigen-specific Treg cells is a promising approach to treat autoimmune disease since the immune suppressive function of Treg… read more here.
Keywords: treg cells; antigen specific; specific treg; arthritis ... See more keywords
The Role of Decidual PD-1+ Treg Cells in Adverse Pregnancy Outcomes due to Toxoplasma gondii Infection
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01075-1
Abstract: Toxoplasma gondii infection during pregnancy can result in adverse pregnancy outcomes. Previously, we have reported that these outcomes are associated with the impaired function of decidual Treg cells; however, the detailed mechanisms involved were unclear.… read more here.
Keywords: treg cells; gondii infection; decidual treg; pregnancy outcomes ... See more keywords
Regulatory T Cells: the Many Faces of Foxp3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00684-7
Abstract: Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary… read more here.
Keywords: cells many; regulatory cells; foxp3; treg cell ... See more keywords
Development of a Concomitant Treg Expansion and Stem Cell Mobilization Protocol Which Enables Peripheral Blood Transplant Amelioration of Gvhd Following Pre-Clinical aHSCT
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.668
Abstract: Graft-versus-host disease (GVHD) remains the major immunological complication preventing more widespread application of allogeneic hematopoietic stem cell transplants (aHSCTs). Mobilized hematopoietic stem / progenitor cells (HSPC) is the predominant choice for adult HSCT (CIBMTR, 2017), but unfortunately still… read more here.
Keywords: gvhd; peripheral blood; treg; cell ... See more keywords
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.05.027
Abstract: Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how their immune-suppressive function is regulated in the tumor microenvironment (TME) remains unknown. Here, we used intravital microscopy to characterize the cellular interactions that provide… read more here.
Keywords: treg cells; tumor associated; ctla; treg cell ... See more keywords