Treg cell therapy: How cell heterogeneity can make the difference
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948131
Abstract: CD4+CD25highCD127low/−FOXP3+ T regulatory cells are responsible for maintaining immune tolerance and controlling excessive immune responses. Treg cell use in pre‐clinical animal models showed the huge therapeutic potential of these cells in immune‐mediated diseases and laid… read more here.
Keywords: cell therapy; treg cells; cell; treg cell ... See more keywords
Regulatory T Cells: the Many Faces of Foxp3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00684-7
Abstract: Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary… read more here.
Keywords: cells many; regulatory cells; foxp3; treg cell ... See more keywords
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.05.027
Abstract: Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how their immune-suppressive function is regulated in the tumor microenvironment (TME) remains unknown. Here, we used intravital microscopy to characterize the cellular interactions that provide… read more here.
Keywords: treg cells; tumor associated; ctla; treg cell ... See more keywords
Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
Sign Up to like & getrecommendations! Published in 2021 at "Life Sciences"
DOI: 10.1016/j.lfs.2021.119437
Abstract: In Coronavirus disease 2019 (COVID-19), a decreased number of regulatory T (Treg) cells and their mediated factors lead to a hyperinflammatory state due to overactivation of the inflammatory cells and factors during the infection. In… read more here.
Keywords: mild severe; group; covid; treg cell ... See more keywords
Lkb1 maintains Treg cell lineage identity
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DOI: 10.1038/ncomms15876
Abstract: Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve Treg lineage-specific features are mostly unknown. Here, we show that… read more here.
Keywords: lineage; cell lineage; expression; lkb1 ... See more keywords
Next-generation regulatory T cell therapy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/s41573-019-0041-4
Abstract: Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune homeostasis. Accordingly, deficiencies in Treg cell development or function result in uncontrolled… read more here.
Keywords: treg cells; cell therapy; regulatory cells; treg cell ... See more keywords
Metabolic support of tumor-infiltrating regulatory T cells by lactic acid
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-020-03045-2
Abstract: SUMMARY Regulatory T (Treg) cells, vital for maintaining immune homeostasis, also represent a major barrier to cancer immunity, as the tumor microenvironment (TME) promotes Treg cell recruitment, differentiation, and activity1,2. Tumor cells have deregulated metabolism… read more here.
Keywords: treg cells; lactic acid; treg cell; function ... See more keywords
Regulatory T cells in autoimmune disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0120-4
Abstract: In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded considerably. Key observations have challenged the traditional definition of Treg cells and have provided insight into the underlying mechanisms responsible for… read more here.
Keywords: treg cells; autoimmune disease; biology; treg cell ... See more keywords
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0316-2
Abstract: Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinal Treg cells to constrain microbiota-dependent… read more here.
Keywords: homeostasis; treg cells; intestinal treg; treg cell ... See more keywords
Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13018
Abstract: Recurrent spontaneous abortion (RSA) is a growing problem worldwide. In a majority of cases, the cause remains unknown but there is increasing evidence that immunologic factors play an important role. Intravenous immunoglobulin (IVIg) therapy has… read more here.
Keywords: recurrent spontaneous; th17 treg; treg cell;
Cambogin suppresses dextran sulphate sodium‐induced colitis by enhancing Treg cell stability and function
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14150
Abstract: Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract, and an impaired immune response plays a critical role in IBD. The current drugs and therapies for IBD treatment are… read more here.
Keywords: sulphate sodium; induced colitis; treg cell; dextran sulphate ... See more keywords