High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2214-0
Abstract: High-grade gliomas (HGG) exert systemic immunosuppression, which is of particular importance as immunotherapeutic strategies such as therapeutic vaccines are increasingly used to treat HGGs. In a first cohort of 61 HGG patients we evaluated a… read more here.
Keywords: treg depletion; high grade; immune responses; hgg patients ... See more keywords
Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00533-20
Abstract: Regulatory T cells (Tregs) can decisively contribute to the establishment and persistence of the HIV reservoir, since they harbor high levels of HIV/SIV, increase the pool of resting CD4+ T cells by reversing their immune… read more here.
Keywords: hiv cure; treg depletion; virus; cell ... See more keywords
Regulatory T-cell depletion in the setting of autologous stem cell transplantation for multiple myeloma: pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2019-000286
Abstract: Background Progression after high-dose melphalan with autologous stem cell transplantation (ASCT) in multiple myeloma (MM) may be due in part to immune dysfunction. Regulatory T (Treg) cells reconstitute rapidly after ASCT and inhibit immune responses… read more here.
Keywords: treg depletion; stem cell; depletion; cell ... See more keywords
Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0131
Abstract: Depletion of Tregs lowered the threshold for immune activation, resulting in high endothelial venule (HEV) neogenesis, driven by a T cell–dependent mechanism. A positive feedback loop was formed that allowed T-cell influx and control of… read more here.
Keywords: treg depletion; hev; depletion; cell ... See more keywords