The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.
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DOI: 10.1016/j.celrep.2020.107826
Abstract: Regulatory T cells (Tregs) represent a major population in the control of immune homeostasis and autoimmunity. Here we show that Fos-like 2 (Fosl2), a TCR-induced AP1 transcription factor, represses Treg development and controls autoimmunity. Mice overexpressing… read more here.
Keywords: treg development; fosl2; ap1 transcription; autoimmunity ... See more keywords