Periosteum-derived mesenchymal stem cell alleviates renal fibrosis through mTOR-mediated Treg differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2023.2212079
Abstract: Abstract Background Mesenchymal stem cells (MSCs) are the hotspots of cellular therapy due to their low immunogenicity, potent immunoregulation, and unique renoprotection. The present study aimed to investigate the effects of periosteum-derived MSCs (PMSCs) in… read more here.
Keywords: renal fibrosis; treg differentiation; renoprotection; differentiation ... See more keywords
Lactoferrin‐derived chimeric peptide (LFch) strongly boosts TGFβ1‐mediated inducible Treg differentiation possibly through downregulating TCR/CD28 signalling
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13566
Abstract: We recently reported that lactoferrin (LF) induces Foxp3+ Treg differentiation through binding to TGFβ receptor III (TβRIII), and this activity was further enhanced by TGFβ1. Generally, a low T‐cell receptor (TCR) signal strength is favourable… read more here.
Keywords: lfch; treg differentiation; foxp3 treg; tgf ... See more keywords
Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn7662
Abstract: Steroid nuclear receptor coactivator 2 (SRC2) is a member of a family of transcription coactivators. While SRC1 inhibits the differentiation of regulatory T cells (Tregs) critical for establishing immune tolerance, we show here that SRC2… read more here.
Keywords: immune tolerance; nuclear receptor; treg differentiation; differentiation ... See more keywords
Bioinformatic Analysis and Cellular Assays Identify Substance P Influencing Th17/Treg Differentiation via the MyD88 Pathway as a Potential Contributor to the Progression of Asthma and Allergic Rhinitis
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DOI: 10.1155/2022/3843954
Abstract: Objective This study is aimed at investigating the role of substance P (SP) in the development of asthma. Methods The Gene Expression Omnibus (GEO) database was used to characterize SP expression in allergic rhinitis (AR)… read more here.
Keywords: th17 treg; myd88; treg differentiation; expression ... See more keywords
BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus
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DOI: 10.7150/thno.63743
Abstract: Background: Serum-derived exosomes are correlated with disease severity of human systemic lupus erythematosus (SLE). The proteins in the T-cell-derived exosomes from SLE patients could contribute to inflammation. Methods: We characterized proteins of T cell-derived exosomes… read more here.
Keywords: systemic lupus; treg differentiation; inflammation; bpi ... See more keywords
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation
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DOI: 10.7150/thno.72148
Abstract: Rationale: GLK (MAP4K3) activates PKCθ-IKKβ axis in T-cell activation and induces IL-17A-mediated autoimmune diseases. Attenuation of Treg differentiation and function by GLK could also contribute to autoimmune diseases. Methods: We analyzed the roles of GLK… read more here.
Keywords: treg differentiation; glk; nuclear export; ikk mediated ... See more keywords
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression
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DOI: 10.7150/thno.78078
Abstract: Regulatory T cells (Tregs) are critical for generating and maintaining peripheral tolerance. Treg-based immunotherapy is valuable for the clinical management of diseases resulting from dysregulation of immune tolerance. However, the lack of potency is a… read more here.
Keywords: hsf1; cd69 treg; treg differentiation; colitis ... See more keywords