Abstract 5863: Blockade of tumor glucocorticoid production inhibits Treg function and tumor growth
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DOI: 10.1158/1538-7445.am2023-5863
Abstract: Glucocorticoids (GCs) are steroid hormones with potent immunosuppressive properties. GCs are primary produced from cholesterol in the adrenals via the de novo synthetic pathway. In some tissues, however, there is also a recycling pathway in… read more here.
Keywords: tumor growth; growth; production; blockade tumor ... See more keywords
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation
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DOI: 10.15252/embr.202050308
Abstract: The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostasis. Previous studies have shown that in natural Tregs (nTregs), FOXP3 can be… read more here.
Keywords: usp44 promotes; deubiquitinase usp44; function; promotes treg ... See more keywords
How GRAIL controls Treg function to maintain self-tolerance
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DOI: 10.3389/fimmu.2022.1046631
Abstract: Regulatory T cells (Tregs) normally maintain self-tolerance. Tregs recognize “self” such that when they are not working properly, such as in autoimmunity, the immune system can attack and destroy one’s own tissues. Current therapies for… read more here.
Keywords: function; treg function; grail; drug ... See more keywords
Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function
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DOI: 10.3389/fimmu.2022.911151
Abstract: The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well established; however, the precise alterations in Treg function in autoimmune individuals and how underlying genetic associations impact the development and function of… read more here.
Keywords: function; treg function; autoimmunity; tissue ... See more keywords