Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.08.030
Abstract: ABSTRACT The feature of pulmonary sarcoidosis is characterized by a Th1/Th17/regulatory T cells (Tregs) ‐driven inflammatory process in lung, resulting in noncaseating granulomas containing CD4+ T cells. Tregs increase in both lung and peripheral blood,… read more here.
Keywords: tregs; il23 antibody; anti il23; regulatory cells ... See more keywords
Different phenotypes of CD4+CD25+Foxp3+ regulatory T cells in recipients post liver transplantation
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.01.048
Abstract: &NA; CD4+ regulatory T cells (Tregs) play an important role in inducing immune tolerance in organ transplantation, which can be divided into CD45RA+Tregs (resting Tregs, rTregs) and CD45RO+Tregs (activated Tregs, aTregs). Currently, the expressions and… read more here.
Keywords: tregs; regulatory cells; liver transplantation; cd45ra tregs ... See more keywords
Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.01.005
Abstract: Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)+ DCs can delay but not completely block diabetes development… read more here.
Keywords: tregs; islet; tolerance via; cd25 ... See more keywords
Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.30
Abstract: Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Th1 and Th17 cells. Studies have confirmed that natural CD4+Foxp3+ Tregs were unstable and dysfunctional in the presence… read more here.
Keywords: tregs; human cd39hi; regulatory cells; inflammatory conditions ... See more keywords
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2219086120
Abstract: Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or… read more here.
Keywords: cell; tregs; exhaustion; tonic signaling ... See more keywords
Interleukin-35 Enhances Regulatory T Cell Function by Potentially Suppressing Their Transdifferentiation into a T Helper 17-Like Phenotype in Kawasaki Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Immunological investigations"
DOI: 10.1080/08820139.2023.2201283
Abstract: Interleukin-35 (IL-35) modulates immune cell activity in inflammation and autoimmune disorders. However, its specific effects on regulatory T cells (Tregs) in Kawasaki disease remain ambiguous. We enrolled 37 patients with Kawasaki disease and 20 healthy… read more here.
Keywords: tregs; kawasaki disease; like phenotype; transdifferentiation ... See more keywords
Humanization and Pre-Clinical Validation of an Anti-HLA-A*02: 01 Chimeric Antigen Receptor for use with Regulatory T cells to Enhance Transplant Tolerance.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000542905.98105.1f
Abstract: Introduction Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term outcomes. Traditional approaches involve the of polyclonal Tregs, which are… read more here.
Keywords: tregs; hla; transplant tolerance; antigen ... See more keywords
Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14031
Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis. Although regulatory T cells (Tregs) have previously been studied in AD, their role remains controversial, likely owing to patient heterogeneity. Thus, we… read more here.
Keywords: circulating tregs; null mutations; tregs; atopic dermatitis ... See more keywords
Trimming the “fatty” intratumoral Tregs for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abb2770
Abstract: Fatty acid receptor CD36 preferentially regulates intratumoral but not peripheral Tregs. Fatty acid receptor CD36 preferentially regulates intratumoral but not peripheral Tregs. read more here.
Keywords: tregs; trimming fatty; tregs cancer; fatty intratumoral ... See more keywords
OP0316 Increased expression of microrna-142–3p is associated with the functional defect of regulatory t cells in anti-neutrophil cytoplasmic antibody associated vasculitis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.3226
Abstract: Background Circulating regulatory T cells (Tregs) in anti-neutrophil cytoplasmic antibody associated vasculitis (AAV) are frequently functionally deficient. The mechanism behind their impaired function is however unknown. Small non-coding microRNA (miR) are post-transcriptional regulators of protein… read more here.
Keywords: aav; none declared; tregs; mir 142 ... See more keywords
AB0346 THE NUMERAL CHANGES OF PERIPHERAL LYMPHOCYTE SUBSETS IN PATIENTS WITH RHEUMATOID ATHRITIS AND THEIR RESTORATIONS AFTER RECEIVED COMBINED IMMUNOMODULATORY THERAPY
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.2138
Abstract: Background: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction characterized by abnormal immune responses to self-antigens1. An imbalance in pro- and anti-inflammatory lymphocyte subsets has been considered to… read more here.
Keywords: tregs; immunomodulatory therapy; rheumatoid arthritis; lymphocyte subsets ... See more keywords