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   Articles with "tregs" as a keyword



Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis

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recommendations! Published in 2018 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2018.08.030

Abstract: ABSTRACT The feature of pulmonary sarcoidosis is characterized by a Th1/Th17/regulatory T cells (Tregs) ‐driven inflammatory process in lung, resulting in noncaseating granulomas containing CD4+ T cells. Tregs increase in both lung and peripheral blood,… read more here.

Keywords: tregs; il23 antibody; anti il23; regulatory cells ... See more keywords

Different phenotypes of CD4+CD25+Foxp3+ regulatory T cells in recipients post liver transplantation

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recommendations! Published in 2019 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2019.01.048

Abstract: &NA; CD4+ regulatory T cells (Tregs) play an important role in inducing immune tolerance in organ transplantation, which can be divided into CD45RA+Tregs (resting Tregs, rTregs) and CD45RO+Tregs (activated Tregs, aTregs). Currently, the expressions and… read more here.

Keywords: tregs; regulatory cells; liver transplantation; cd45ra tregs ... See more keywords

Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.

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recommendations! Published in 2018 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2018.01.005

Abstract: Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)+ DCs can delay but not completely block diabetes development… read more here.

Keywords: tregs; islet; tolerance via; cd25 ... See more keywords

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

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recommendations! Published in 2017 at "Cellular and Molecular Immunology"

DOI: 10.1038/cmi.2016.30

Abstract: Autoimmune diseases are characterized by an imbalance between regulatory T cells and effector T-cell subsets, such as Th1 and Th17 cells. Studies have confirmed that natural CD4+Foxp3+ Tregs were unstable and dysfunctional in the presence… read more here.

Keywords: tregs; human cd39hi; regulatory cells; inflammatory conditions ... See more keywords

CD74 supports accumulation and function of regulatory T cells in tumors

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-47981-3

Abstract: Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment where they reside; as a consequence, their molecular and functional profiles differ… read more here.

Keywords: tregs; accumulation function; tumor; regulatory cells ... See more keywords

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60082-z

Abstract: Regulatory T (Treg)-based cell therapy holds promise for autoimmune and inflammatory diseases, yet challenges remain regarding the functional stability and persistence of transferred Tregs. Here we engineer Tregs to express a partial agonist form of… read more here.

Keywords: tregs il2pa; tregs; persistence; treg ... See more keywords

CTLA-4 expression on tregs is needed for suppression of autoimmune uveitis

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-02816-z

Abstract: Uveitis is a leading cause of blindness in the world and autoimmune uveitis is an ocular tissue specific autoimmune disease. Utilizing experimental autoimmune uveitis (EAU), we can interrogate different immune responses in the mouse that… read more here.

Keywords: tregs; ctla; autoimmune uveitis; disease ... See more keywords

Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2219086120

Abstract: Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or… read more here.

Keywords: cell; tregs; exhaustion; tonic signaling ... See more keywords

Interleukin-35 Enhances Regulatory T Cell Function by Potentially Suppressing Their Transdifferentiation into a T Helper 17-Like Phenotype in Kawasaki Disease.

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recommendations! Published in 2023 at "Immunological investigations"

DOI: 10.1080/08820139.2023.2201283

Abstract: Interleukin-35 (IL-35) modulates immune cell activity in inflammation and autoimmune disorders. However, its specific effects on regulatory T cells (Tregs) in Kawasaki disease remain ambiguous. We enrolled 37 patients with Kawasaki disease and 20 healthy… read more here.

Keywords: tregs; kawasaki disease; like phenotype; transdifferentiation ... See more keywords

Correlation of the abundance of MDSCs, Tregs, PD-1, and PD-L1 with the efficacy of chemotherapy and prognosis in gastric cancer.

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recommendations! Published in 2024 at "Laboratory medicine"

DOI: 10.1093/labmed/lmae090

Abstract: OBJECTIVE The aim of this study was to investigate the relationship between tumor microenvironment markers (myeloid-derived suppressor cells [MDSCs], regulatory T cells [Tregs], programmed cell death 1 [PD-1], and programmed death ligand 1 [PD-L1]) and… read more here.

Keywords: cancer; mdsc treg; gastric cancer; chemotherapy ... See more keywords

Humanization and Pre-Clinical Validation of an Anti-HLA-A*02: 01 Chimeric Antigen Receptor for use with Regulatory T cells to Enhance Transplant Tolerance.

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recommendations! Published in 2018 at "Transplantation"

DOI: 10.1097/01.tp.0000542905.98105.1f

Abstract: Introduction Achieving transplant tolerance with regulatory T cell (Treg) adoptive immunotherapy is currently under investigation as a therapy to reduce graft rejection and improve long-term outcomes. Traditional approaches involve the of polyclonal Tregs, which are… read more here.

Keywords: tregs; hla; transplant tolerance; antigen ... See more keywords