Engineering the Mycomembrane of Live Mycobacteria with an Expanded Set of Trehalose Monomycolate Analogues
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DOI: 10.1002/cbic.201800687
Abstract: Mycobacteria and related organisms in the Corynebacterineae suborder are characterized by a distinctive outer membrane referred to as the mycomembrane. Biosynthesis of the mycomembrane occurs through an essential process called mycoloylation, which involves antigen 85… read more here.
Keywords: trehalose monomycolate; cell; cell labeling; tmm ... See more keywords
Inhibitor binding and disruption of coupled motions in MmpL3 protein: Unraveling the mechanism of trehalose monomycolate transport
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DOI: 10.1002/pro.5166
Abstract: Mycobacterial membrane protein Large 3 (MmpL3) of Mycobacterium tuberculosis (Mtb) is crucial for the translocation of trehalose monomycolate (TMM) across the inner bacterial cell membrane, making it a promising target for anti‐tuberculosis (TB) drug development.… read more here.
Keywords: inhibitor binding; coupled motions; transport; trehalose monomycolate ... See more keywords