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Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-4254-8_4
Abstract: K2P (KCNK) potassium channels form "background" or "leak" currents that have critical roles in cell excitability control in the brain, cardiovascular system, and somatosensory neurons. Similar to many ion channel families, studies of K2Ps have…
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Keywords:
channel;
function;
trek;
polysite pharmacology ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00430-2
Abstract: In the eye, intraocular pressure (IOP) is tightly regulated and its persistent increase leads to ocular hypertension and glaucoma. We have previously shown that trabecular meshwork (TM) cells might detect aqueous humor fluid shear stress…
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Keywords:
intraocular pressure;
trabecular meshwork;
meshwork cells;
trek ... See more keywords
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3
Published in 2023 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004577
Abstract: Background: A variety of molecular targets for volatile anesthetics have been suggested, including the anesthetic-sensitive potassium leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling…
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Keywords:
minimum alveolar;
isoflurane;
halothane;
trek trek ... See more keywords
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Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.13980
Abstract: Spinal cord injury (SCI) involves complex pathological process which can be complicated by secondary injury. TREK‐1 is a member of the two‐pore domain potassium (K2P) channel family, which can be modulated by a number of…
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Keywords:
mice;
trek;
injury;
deficiency ... See more keywords
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Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci95945
Abstract: Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and…
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Keywords:
dysfunction;
two pore;
pore domain;
domain potassium ... See more keywords
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Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1485-5
Abstract: BackgroundIntracerebral hemorrhage (ICH) is a devastating medical emergency with high mortality and severe neurological deficit. ICH-related poor outcomes are due to a combination of pathological processes that could be complicated by secondary insults. TWIK-related K+…
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Keywords:
blood brain;
intracerebral hemorrhage;
hemorrhage;
trek ... See more keywords
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Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201606690
Abstract: In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium…
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Keywords:
stretch;
sodium permeable;
tachycardia;
trek ... See more keywords
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Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00643
Abstract: Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE…
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Keywords:
antidepressant activity;
spadin analogs;
trek;
stability ... See more keywords
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Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00434
Abstract: TREK-1 channel activity is a critical regulator of neuronal, cardiac, and smooth muscle physiology and pathology. The antidepressant peptide, spadin, has been proposed to be a TREK-1-specific blocker. Here we sought to examine the mechanism…
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Keywords:
trek trek;
activation trek;
trek;
acid ... See more keywords
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Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.705421
Abstract: Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin) is a stable prostacyclin analogue with potent vasodilatory and anti-proliferative activity, approved by the FDA…
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Keywords:
trek trek;
arterial hypertension;
treatment;
pulmonary arterial ... See more keywords
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Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051279
Abstract: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation and abnormal accumulation of extracellular matrix in the lungs. After lung injury, M2 macrophages mediate the pathogenesis of pulmonary fibrosis by secreting fibrotic…
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Keywords:
lung fibrosis;
pulmonary fibrosis;
potassium channel;
fibrosis ... See more keywords