Association of genetic polymorphisms in the pore domains of mechano‐gated TREK‐1 channel with overactive lower urinary tract symptoms in humans
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23862
Abstract: Mechanosensitivity of the urinary bladder is regulated by many factors including mechano‐gated two‐pore domain (K2P, KCNK) potassium channels. TWIK‐related K+ channel, TREK‐1, is a predominantly expressed member of K2P channel family in the human detrusor,… read more here.
Keywords: urinary tract; overactive lower; mechano gated; tract symptoms ... See more keywords
Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179320
Abstract: The two-pore domain K+ (K2P) channel, which is involved in setting the resting membrane potential in neurons, is an essential target for receptor agonists. Activation of the γ-aminobutyric acid (GABA) receptors (GABAAR and GABABR) reduces… read more here.
Keywords: gabaergic neurons; b35 cells; trek; activity ... See more keywords