Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
Sign Up to like & getrecommendations! Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201606690
Abstract: In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium… read more here.
Keywords: stretch; sodium permeable; tachycardia; trek ... See more keywords
Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00434
Abstract: TREK-1 channel activity is a critical regulator of neuronal, cardiac, and smooth muscle physiology and pathology. The antidepressant peptide, spadin, has been proposed to be a TREK-1-specific blocker. Here we sought to examine the mechanism… read more here.
Keywords: trek trek; activation trek; trek; acid ... See more keywords