TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane.
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DOI: 10.1097/aln.0000000000004577
Abstract: Background: A variety of molecular targets for volatile anesthetics have been suggested, including the anesthetic-sensitive potassium leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling… read more here.
Keywords: minimum alveolar; isoflurane; halothane; trek trek ... See more keywords
Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels
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DOI: 10.3389/fphar.2020.00434
Abstract: TREK-1 channel activity is a critical regulator of neuronal, cardiac, and smooth muscle physiology and pathology. The antidepressant peptide, spadin, has been proposed to be a TREK-1-specific blocker. Here we sought to examine the mechanism… read more here.
Keywords: trek trek; activation trek; trek; acid ... See more keywords
The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.705421
Abstract: Pulmonary arterial hypertension (PAH) is an aggressive vascular remodeling disease that carries a high morbidity and mortality rate. Treprostinil (Remodulin) is a stable prostacyclin analogue with potent vasodilatory and anti-proliferative activity, approved by the FDA… read more here.
Keywords: trek trek; arterial hypertension; treatment; pulmonary arterial ... See more keywords