TREM2 triggers microglial density and age‐related neuronal loss
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23563
Abstract: The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with… read more here.
Keywords: trem2 knock; trem2; age related; neuronal loss ... See more keywords
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells
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DOI: 10.1002/glia.24252
Abstract: The receptor Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is associated with several neurodegenerative diseases including Alzheimer's Disease and TREM2 stimulation represents a novel therapeutic opportunity. TREM2 can be activated by antibodies targeting the… read more here.
Keywords: trem2; receptor expressed; triggering receptor; myeloid cells ... See more keywords
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
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DOI: 10.1002/glia.24318
Abstract: Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD). Individuals heterozygous for the R47H variant of TREM2 have… read more here.
Keywords: r47h trem2; trem2; phagocytosis; neuronal loss ... See more keywords
Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-022-03173-w
Abstract: Immune checkpoint blockade (ICB) has been improving patient outcomes of non-small cell lung cancer (NSCLC), but its effectiveness is highly subjective to individual tumor microenvironment. As dominant immune cells in NSCLC, tumor-associated macrophages (TAMs) display… read more here.
Keywords: cancer; trem2; small cell; non small ... See more keywords
Pinitol Prevents Lipopolysaccharide (LPS)-Induced Inflammatory Responses in BV2 Microglia Mediated by TREM2
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity Research"
DOI: 10.1007/s12640-020-00187-z
Abstract: Microglia-involved neuroinflammation in the central nervous system (CNS) has been shown to aggravate brain damage and is associated with the pathogenesis of various neurodegenerative diseases. Thus, suppression of microglial activity has the potential to be… read more here.
Keywords: trem2; inflammatory responses; lps induced; pinitol prevents ... See more keywords
Differential regulation of TREM2 and CSF1R in CNS macrophages in an SIV/macaque model of HIV CNS disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-020-00844-1
Abstract: HIV-associated neuroinflammation is primarily driven by CNS macrophages including microglia. Regulation of these immune responses, however, remains to be characterized in detail. Using the SIV/macaque model of HIV, we evaluated CNS expression of triggering receptor… read more here.
Keywords: trem2; csf1r; hiv; disease ... See more keywords
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.10.011
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of many antineoplastic agents. Patients treated with chemotherapy often report pain and paresthesias in a "glove-and-stocking" distribution. Diverse mechanisms contribute to the development and maintenance… read more here.
Keywords: trem2; peripheral neuropathy; cisplatin; induced peripheral ... See more keywords
TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.226
Abstract: Neuroinflammation and overactivated microglia underlies the pathogenesis of Parkinson's disease (PD). Furthermore, microglia could polarize into classic inflammatory M1 and immunosuppressive M2 phenotype. Thus, inhibiting the overactivated inflammatory M1 microglia by promoting the transformation of… read more here.
Keywords: trem2; neuroinflammation; modulates microglia; polarization ... See more keywords
Microglia TREM2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.130
Abstract: Neuroinflammation plays a critical role in ischemic stroke pathology and could be a promising target in ischemic stroke. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor in the CNS that is… read more here.
Keywords: trem2; cerebral ischemia; neuroinflammation; reperfusion ... See more keywords
Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.04.019
Abstract: Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the loss of… read more here.
Keywords: trem2; cell; mouse brain; widespread disruption ... See more keywords
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
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DOI: 10.1016/j.neuron.2019.12.007
Abstract: Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms… read more here.
Keywords: regulates microglial; trem2 regulates; cholesterol; metabolism ... See more keywords