A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease
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DOI: 10.1126/scitranslmed.abq0095
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) plays crucial roles in Alzheimer’s disease (AD) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oAβ) and amyloid plaques. Studies in rodent models of AD… read more here.
Keywords: trem2; amyloid pathology; alzheimer disease; trem2 agonistic ... See more keywords