TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
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DOI: 10.1016/j.neuron.2019.12.007
Abstract: Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms… read more here.
Keywords: regulates microglial; trem2 regulates; cholesterol; metabolism ... See more keywords