TREM2‐dependent microglial function is essential for remyelination and subsequent neuroprotection
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24335
Abstract: Disability in multiple sclerosis (MS) is driven in part by the failure of remyelination and progressive neurodegeneration. Microglia, and specifically triggering receptor expressed on myeloid cells 2 (TREM2), a factor highly expressed in microglia, have… read more here.
Keywords: neuroprotection; trem2 knockout; remyelination; trem2 dependent ... See more keywords
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.ade6285
Abstract: Sleep loss is associated with cognitive decline in the aging population and is a risk factor for Alzheimer’s disease (AD). Considering the crucial role of immunomodulating genes such as that encoding the triggering receptor expressed… read more here.
Keywords: sleep loss; sleep deprivation; trem2; trem2 dependent ... See more keywords