A Strategy Involving Microporous Microneedles Integrated with CAR‐TREM2‐Macrophages for Scar Management by Regulating Fibrotic Microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202406153
Abstract: Dipeptidyl peptidase 4 (DPP4) positive fibroblasts play a pivotal role in scar development following skin injury. Heterogeneous vascular endothelial cells (ECs) within scarred areas retain the capacity to drive tissue regeneration and repair. Simultaneously, TREM2… read more here.
Keywords: trem2 macrophages; microenvironment; scar; car trem2 ... See more keywords
Defining gastric cancer ecology: the crucial roles of TREM2+ macrophages and fibroblasts in tumor microenvironments
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07512-2
Abstract: Gastric cancer (GC) remains a major global health challenge, characterized by a complex tumor microenvironment (TME) that significantly influences disease progression and therapeutic outcomes. This study focuses on TREM2+ lipid-associated macrophages (LAM) and cancer-associated fibroblasts… read more here.
Keywords: cancer; defining gastric; cancer ecology; trem2 macrophages ... See more keywords
Hepatic TREM2+ macrophages express matrix metalloproteinases to control fibrotic scar formation
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12616
Abstract: Liver cirrhosis is characterized by the extensive deposition of extracellular matrix such as fibril collagen, causing dysfunction and failure of the liver. Hepatic macrophages play pivotal roles in the transition from inflammatory to restorative properties… read more here.
Keywords: fibrotic scar; cell; trem2; scar ... See more keywords