Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
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DOI: 10.1016/j.celrep.2018.07.094
Abstract: Summary Dysfunction of microglia, the brain’s immune cells, is linked to neurodegeneration. Homozygous missense mutations in TREM2 cause Nasu-Hakola disease (NHD), an early-onset dementia. To study the consequences of these TREM2 variants, we generated induced… read more here.
Keywords: trem2 missense; missense mutations; pluripotent stem; induced pluripotent ... See more keywords