Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.05.033
Abstract: Treosulfan (TREO) is a prodrug applied in the treatment of ovarian cancer and a myeloablative conditioning prior to stem cell transplantation. A sequential activation of TREO to intermediate monoepoxide (S,S-EBDM) and then to (2S,3S)-1,2:3,4-diepoxybutane (S,S-DEB)… read more here.
Keywords: temperature; effect temperature; treosulfan; activation ... See more keywords
Pre-formulation investigations for establishing a protocol for treosulfan handling and activation
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DOI: 10.1080/10837450.2018.1551903
Abstract: Abstract Introduction: Treosulfan is an alkylating agent that is used for the treatment of ovarian cancer and for conditioning prior to stem cell transplantation. It is a prodrug that is activated non-enzymatically to two active… read more here.
Keywords: formulation investigations; pre formulation; protocol; treosulfan ... See more keywords
Treosulfan‐based reduced toxicity hematopoietic stem cell transplantation in X‐linked agammaglobulinemia: A cost‐effective alternative to long‐term immunoglobulin replacement in developing countries
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DOI: 10.1111/petr.13625
Abstract: X‐linked agammaglobulinemia (XLA) is a primary antibody disorder due to a mutation in the Bruton tyrosine kinase gene that requires lifelong immunoglobulin replacement resulting in a significant economic burden and treatment abandonment. Hematopoietic stem cell… read more here.
Keywords: immunoglobulin replacement; treosulfan; stem cell; transplantation ... See more keywords
Comparison of Melphalan Combined with Treosulfan or Busulfan as High-Dose Chemotherapy before Autologous Stem Cell Transplantation in AML
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DOI: 10.3390/cancers14041024
Abstract: Simple Summary Different consolidation strategies are available for acute myeloid leukemia (AML) patients fit for intensive treatment. For favorable- or intermediate-risk AML, high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) is one of… read more here.
Keywords: aml; treosulfan; melphalan; high dose ... See more keywords