Potential Treponema denticola-based periodontal vaccine to resolve a global public health challenge: a narrative literature review.
Sign Up to like & getrecommendations! Published in 2022 at "Expert review of vaccines"
DOI: 10.1080/14760584.2022.2044798
Abstract: INTRODUCTION Periodontitis is a diseased condition of the gum which imposes considerable costs on healthcare systems. It progresses further beyond the inflammation of supportive tissues of the teeth, and the collateral damages are closely associated… read more here.
Keywords: periodontal vaccine; vaccine; review; treponema denticola ... See more keywords
Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola.
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DOI: 10.1111/omi.12406
Abstract: The Msp protein complex and the serine protease dentilisin are the best-characterized virulence factors in Treponema denticola, the major etiological agent of chronic periodontitis. In addition to these outer sheath factors, the cysteine protease dentipain… read more here.
Keywords: cysteine protease; denticola; treponema denticola; dentipain ... See more keywords
Identification and Characterization of the Alternative σ28 Factor in Treponema denticola
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DOI: 10.1128/jb.00248-22
Abstract: Spirochetes are a group of medically important but understudied bacteria. One of the unique aspects of spirochetes is that they have periplasmic flagella (PF, also known as endoflagella) which give rise to their unique spiral… read more here.
Keywords: denticola; role; treponema denticola; factor ... See more keywords
Treponema denticola Promotes OSCC Development via the TGF-β Signaling Pathway
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DOI: 10.1177/00220345211067401
Abstract: Numerous studies have demonstrated an association between periodontitis and oral squamous cell carcinoma (OSCC), and periodontal pathogens such as Treponema denticola are implicated in the pathogenesis of OSCC. Previous studies have mainly focused on T.… read more here.
Keywords: cell; cell proliferation; denticola; development ... See more keywords
Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice.
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DOI: 10.1177/00220345221076772
Abstract: Alzheimer's disease (AD) is the most common type of dementia. Tau hyperphosphorylation and amyloid β (Aβ) deposition are the key pathological hallmarks of AD. Recent studies have shown that periodontitis is a significant risk factor… read more here.
Keywords: tau; treponema denticola; tau hyperphosphorylation; mice ... See more keywords
Treponema denticola as a prognostic biomarker for periodontitis in dogs
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DOI: 10.1371/journal.pone.0262859
Abstract: Periodontal disease is one of the most common disorders in the oral cavity of dogs and humans. Periodontitis, the irreversible periodontal disease, arises progressively from gingivitis, the reversible inflammatory condition caused by dental plaque. Although… read more here.
Keywords: periodontal disease; treponema denticola; prognostic biomarker; periodontitis ... See more keywords
The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology
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DOI: 10.3390/ijerph19159386
Abstract: Alzheimer’s Disease (AD) is a complex neurodegenerative disease and remains the most common form of dementia. The pathological features include amyloid (Aβ) accumulation, neurofibrillary tangles (NFTs), neural and synaptic loss, microglial cell activation, and an… read more here.
Keywords: disease; alzheimer disease; treponema denticola; brain ... See more keywords